SnoN Antibody (C6): sc-133119
- SnoN Antibody (C6) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 368-684 of SnoN of human origin
- recommended for detection of SnoN and SnoN2 of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-133119 X, 200 µg/0.1 ml)
- m-IgG2b BP-HRP is the preferred secondary detection reagent for SnoN Antibody (C6) for WB applications. This reagent is now offered in a bundle with SnoN Antibody (C6) (see ordering information below).
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SnoN Antibody (C6) is a mouse monoclonal IgG2b antibody that detects SnoN in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SnoN is a crucial member of the Ski family of oncogenes, which plays a significant role in regulating TGFβ signaling pathways. SnoN is primarily located in the nucleus, where SnoN forms homodimers and heterodimers, allowing SnoN to bind to DNA and function as both a transcriptional activator and repressor. The nuclear localization of SnoN is vital for interaction with Smad proteins, particularly Smad2 and Smad4, which are key players in the TGFβ signaling cascade. By associating with the MH2 domain of these Smad proteins, SnoN recruits the transcriptional co-repressor N-CoR, effectively inhibiting transcription and regulating gene expression related to cell growth and extracellular matrix production. Furthermore, nuclear localization of SnoN allows for rapid degradation in response to TGFβ signaling, highlighting SnoN′s role as a negative regulator of TGFβ-induced transcriptional activation. anti-SnoN antibody (C6) is an essential tool for researchers studying the intricate mechanisms of TGFβ signaling and its implications in various cellular processes and diseases.
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SnoN Antibody (C6) References:
- SnoN in TGF-beta signaling and cancer biology. | Pot, I. and Bonni, S. 2008. Curr Mol Med. 8: 319-28. PMID: 18537639
- SnoN in mammalian development, function and diseases. | Jahchan, NS. and Luo, K. 2010. Curr Opin Pharmacol. 10: 670-5. PMID: 20822955
- SnoN in regulation of embryonic development and tissue morphogenesis. | Zhu, Q. and Luo, K. 2012. FEBS Lett. 586: 1971-6. PMID: 22710172
- SnoN activates p53 directly to regulate aging and tumorigenesis. | Pan, D., et al. 2012. Aging Cell. 11: 902-911. PMID: 22805162
- SnoN as a novel negative regulator of TGF-β/Smad signaling: a target for tailoring organ fibrosis. | Zeglinski, MR., et al. 2015. Am J Physiol Heart Circ Physiol. 308: H75-82. PMID: 25380815
- SnoN Antagonizes the Hippo Kinase Complex to Promote TAZ Signaling during Breast Carcinogenesis. | Zhu, Q., et al. 2016. Dev Cell. 37: 399-412. PMID: 27237790
- SnoN Stabilizes the SMAD3/SMAD4 Protein Complex. | Walldén, K., et al. 2017. Sci Rep. 7: 46370. PMID: 28397834
- The regulatory protein SnoN antagonizes activin/Smad2 protein signaling and thereby promotes adipocyte differentiation and obesity in mice. | Zhu, Q., et al. 2018. J Biol Chem. 293: 14100-14111. PMID: 30030373
- The Transcriptional Regulator SnoN Promotes the Proliferation of Cerebellar Granule Neuron Precursors in the Postnatal Mouse Brain. | Chen, X., et al. 2019. J Neurosci. 39: 44-62. PMID: 30425119
- Computational investigation of a ternary model of SnoN-SMAD3-SMAD4 complex. | Ji, M., et al. 2019. Comput Biol Chem. 83: 107159. PMID: 31743832
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SnoN Antibody (C6) | sc-133119 | 200 µg/ml | $322.00 | |||
SnoN Antibody (C6): m-IgG2b BP-HRP Bundle | sc-548486 | 200 µg Ab; 10 µg BP | $361.00 | |||
SnoN Antibody (C6) X | sc-133119 X | 200 µg/0.1 ml | $322.00 |