SNAP 25 Antibody (B-8): sc-390644

SNAP 25 Antibody (B-8) is a mouse monoclonal IgG3 kappa light chain antibody that detects SNAP 25 (including SNAP 25A and SNAP 25B splice variants) from mouse, rat, and human origins by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-SNAP 25 antibody (B-8) is available in a non-conjugated form, allowing for versatile applications in various experimental settings. SNAP 25 plays a crucial role in neurotransmitter release, functioning as a key component of the SNARE complex, which facilitates synaptic vesicle fusion with the presynaptic membrane. SNAP 25′s ability to mediate exocytosis is vital for neuronal communication, ensuring proper neurotransmitter release into the synaptic cleft, thereby influencing synaptic transmission and plasticity. SNAP 25′s interaction with syntaxins and vesicle-associated membrane proteins (VAMPs) underscores its importance in synaptic function machinery. By anchoring to cellular membrane cytoplasmic surfaces, SNAP 25 stabilizes the SNARE complex and regulates neurotransmitter release, making SNAP 25 a significant target for studying synaptic dynamics and potential therapeutic interventions in neurological disorders.

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SNAP 25 Antibody (B-8) References:

1. SNAP-25 reduction in the hippocampus of patients with schizophrenia.  |  Thompson, PM., et al. 2003. Prog Neuropsychopharmacol Biol Psychiatry. 27: 411-7. PMID: 12691775
2. CSPα knockout causes neurodegeneration by impairing SNAP-25 function.  |  Sharma, M., et al. 2012. EMBO J. 31: 829-41. PMID: 22187053
3. Epileptiform activity and cognitive deficits in SNAP-25(+/-) mice are normalized by antiepileptic drugs.  |  Corradini, I., et al. 2014. Cereb Cortex. 24: 364-76. PMID: 23064108
4. Synaptosomal-associated protein 25 (Snap-25) gene polymorphism frequency in fibromyalgia syndrome and relationship with clinical symptoms.  |  Balkarli, A., et al. 2014. BMC Musculoskelet Disord. 15: 191. PMID: 24885975
5. Structural characterization of the Rabphilin-3A-SNAP25 interaction.  |  Ferrer-Orta, C., et al. 2017. Proc Natl Acad Sci U S A. 114: E5343-E5351. PMID: 28634303
6. SNAP-25 isoforms differentially regulate synaptic transmission and long-term synaptic plasticity at central synapses.  |  Irfan, M., et al. 2019. Sci Rep. 9: 6403. PMID: 31024034
7. Detection of epistasis between ACTN3 and SNAP-25 with an insight towards gymnastic aptitude identification.  |  Płóciennik, ŁA., et al. 2020. PLoS One. 15: e0237808. PMID: 32866209
8. Syntaxin-1a and SNAP-25 expression level is increased in the blood samples of ischemic stroke patients.  |  Cappelletti, P., et al. 2022. Sci Rep. 12: 14483. PMID: 36008522
9. Sex-specific effects of SNAP-25 genotype on verbal memory and Alzheimer's disease biomarkers in clinically normal older adults.  |  Saloner, R., et al. 2023. Alzheimers Dement. 19: 3448-3457. PMID: 36807763
10. SNAP-25 is essential for cortical granule exocytosis in mouse eggs.  |  Ikebuchi, Y., et al. 1998. Am J Physiol. 274: C1496-500. PMID: 9696691

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SNAP 25 Antibody (B-8) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-SNAP 25 Antibody (B-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SNAP 25 Antibody (B-8) Specifications

Alternate Product Name: SNAP 25

Product Clone Name: B-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 173-206

Epitope Target: SNAP 25

Epitope Species: human

Product Reactivity/Detection: SNAP 25 (including SNAP 25A and SNAP 25B splice variants)

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine, porcine and avian

Additional Non-Mammalian Reactivity: avian

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for SNAP 25 Antibody (B-8): P: Blocking Peptide

The preferred SNAP 25 antibody is SNAP 25 Antibody (H-1): sc-376713.