SMPDL3B Antibody (B-1): sc-376870

SMPDL3B Antibody (B-1) is a mouse monoclonal IgG1 antibody that detects SMPDL3B in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SMPDL3B, also known as ASMLPD or ASML3B, is a 455 amino acid secreted protein that belongs to the acid sphingomyelinase family and is primarily expressed in the granulosa cells of the ovarian follicle. Anti-SMPDL3B antibody (B-1) recognizes a protein that plays a crucial role in lipid metabolism by hydrolyzing sphingomyelin into ceramide and phosphocholine, which are vital for various cellular processes, including apoptosis in germ cell lines. SMPDL3B′s function is significant due to its homology to acid sphingomyelinase (ASM), a lysosomal protein whose deficiency is linked to severe conditions such as type A and type B Niemann-Pick disease. Type A is a devastating neurodegenerative disorder that manifests in infancy and often leads to death by age three, while type B presents with a later onset and is characterized by non-neuropathic symptoms. SMPDL3B monoclonal antibody (B-1) serves as an essential tool for researchers investigating the roles of sphingolipid metabolism in health and disease, providing insights into the molecular mechanisms underlying these critical biological processes.

The preferred SMPDL3B antibody is SMPDL3B Antibody (H-3): sc-137113.