SMP30 Antibody (17): sc-130344

SMP30 Antibody (17) is a mouse monoclonal IgG2a antibody that detects senescence marker protein-30 (SMP30) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-SMP30 antibody (17) plays a crucial role in understanding SMP30 function, which is vital for maintaining intracellular calcium homeostasis by regulating plasma membrane calcium pump activity. This regulation helps protect cells from apoptosis, thereby influencing cell survival and tissue health. SMP30 expression is notably observed in the liver, kidney, and submandibular gland, with localization in the hepatocytes and renal proximal tubular epithelium of the kidney. SMP30 levels increase during tissue maturation and decrease with aging in an androgen-independent manner, highlighting SMP30′s potential as a biomarker for cellular senescence and age-related changes. The promoter sequence of the mouse SMP30 gene contains binding sites for various transcription factors, including Sp1, AP2, CCAAT box, Lyf-1, and GATA-1, which may play a role in regulating SMP30 expression and associated functions.

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SMP30 Antibody (17) References:

1. Expression and structure of senescence marker protein-30 (SMP30) and its biological significance.  |  Fujita, T., et al. 1999. Mech Ageing Dev. 107: 271-80. PMID: 10360682
2. Senescence marker protein 30 (SMP30) expression in eukaryotic cells: existence of multiple species and membrane localization.  |  Arun, P., et al. 2011. PLoS One. 6: e16545. PMID: 21347421
3. Anti-inflammatory activity of SMP30 modulates NF-κB through protein tyrosine kinase/phosphatase balance.  |  Jung, KJ., et al. 2015. J Mol Med (Berl). 93: 343-56. PMID: 25394676
4. Senescence marker protein 30 (SMP30) serves as a potential prognostic indicator in hepatocellular carcinoma.  |  Mo, Z., et al. 2016. Sci Rep. 6: 39376. PMID: 27991558
5. Bone Degeneration and Its Recovery in SMP30/GNL-Knockout Mice.  |  Nishijima, K., et al. 2017. J Nutr Health Aging. 21: 573-578. PMID: 28448089
6. Senescence marker protein 30 (SMP30) protects against high glucose-induced apoptosis, oxidative stress and inflammatory response in retinal ganglion cells by enhancing Nrf2 activation via regulation of Akt/GSK-3β pathway.  |  Zhang, L., et al. 2021. Int Immunopharmacol. 101: 108238. PMID: 34688152
7. SMP30-mediated synthesis of vitamin C activates the liver PPARα/FGF21 axis to regulate thermogenesis in mice.  |  Lee, B., et al. 2022. Exp Mol Med. 54: 2036-2046. PMID: 36434042
8. SMP30 Interacts with ROCK1 to Inhibit HCC Invasiveness by Effecting the Epithelial-Mesenchymal Transition.  |  Zheng, S., et al. 2024. Front Biosci (Landmark Ed). 29: 214. PMID: 38940025
9. SMP30 alleviates cerebral ischemia/reperfusion-induced neuronal injury by inhibiting HDAC4/PSD-95 to preserve mitochondrial function.  |  Chen, R., et al. 2025. J Neuropathol Exp Neurol. 84: 59-73. PMID: 39254519
10. SMP30 Alleviates Oxidative Stress and Regulates Ca2+-ATPase Activity in UVR-B-Induced Cataracts in Rats.  |  Lan, T., et al. 2024. Curr Eye Res. 1-8. PMID: 39690481

The preferred SMP30 antibody is SMP30 Antibody (G-10): sc-374019.