SMOC-2 Antibody (F-11): sc-376104
- SMOC-2 Antibody (F-11) is a mouse monoclonal IgG2a κ SMOC-2 antibody, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 71-123 mapping near the N-terminus of SMOC-2 of human origin
- SMOC-2 Antibody (F-11) is recommended for detection of SMOC-2 of mouse, rat, human and origin by WB, IP, IF and ELISA
- Anti-SMOC-2 Antibody (F-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for SMOC-2 Antibody (F-11) for WB applications. This reagent is now offered in a bundle with SMOC-2 Antibody (F-11) (see ordering information below).
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SMOC-2 Antibody (F-11) is a mouse monoclonal IgG2a kappa light chain antibody that detects SMOC-2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SMOC-2 (F-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SMOC-2, also known as SPARC-related modular calcium-binding protein-2, SMAP2, MST117, MSTP117, or MSTP140, is a secreted glycoprotein that plays a crucial role in the extracellular matrix, where SMOC-2 is involved in tissue remodeling, angiogenesis, and bone mineralization. Notably, SMOC-2 contains two EF-hand domains, a Kazal-like domain, and two thyroglobulin type-1 domains, which contribute to SMOC-2′s ability to bind calcium and interact with various growth factors. SMOC-2 is predominantly expressed in tissues such as the spleen, ovary, muscle, and heart, highlighting SMOC-2′s importance in physiological processes. SMOC-2 interacts with vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF), suggesting SMOC-2′s significant role in promoting angiogenic activity, cell proliferation, and migration. Furthermore, SMOC-2 is essential for effective growth factor-induced DNA synthesis, and SMOC-2 overexpression has been shown to significantly enhance DNA synthesis, making SMOC-2 a potential target for anti-angiogenic therapies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SMOC-2 Antibody (F-11) References:
- Characterization of SMOC-1, a novel modular calcium-binding protein in basement membranes. | Vannahme, C., et al. 2002. J Biol Chem. 277: 37977-86. PMID: 12130637
- Characterization of SMOC-2, a modular extracellular calcium-binding protein. | Vannahme, C., et al. 2003. Biochem J. 373: 805-14. PMID: 12741954
- Transcriptional status of known and novel genes tagged with consensus of 33.15 repeat loci employing minisatellite-associated sequence amplification (MASA) and real-time PCR in water buffalo, Bubalus bubalis. | Srivastava, J., et al. 2006. DNA Cell Biol. 25: 31-48. PMID: 16405399
- Secreted modular calcium-binding protein-1 localization during mouse embryogenesis. | Gersdorff, N., et al. 2006. Histochem Cell Biol. 126: 705-12. PMID: 16736127
- The novel SPARC family member SMOC-2 potentiates angiogenic growth factor activity. | Rocnik, EF., et al. 2006. J Biol Chem. 281: 22855-64. PMID: 16774925
- Evaluation of bone-derived and marrow-derived vascular endothelial cells by microarray analysis. | Sosnoski, DM. and Gay, CV. 2007. J Cell Biochem. 102: 463-72. PMID: 17372935
- Transcriptome analysis of endothelial cell gene expression induced by growth on matrigel matrices: identification and characterization of MAGP-2 and lumican as novel regulators of angiogenesis. | Albig, AR., et al. 2007. Angiogenesis. 10: 197-216. PMID: 17632767
- The SPARC-related factor SMOC-2 promotes growth factor-induced cyclin D1 expression and DNA synthesis via integrin-linked kinase. | Liu, P., et al. 2008. Mol Biol Cell. 19: 248-61. PMID: 17989364
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SMOC-2 Antibody (F-11) | sc-376104 | 200 µg/ml | $322.00 | |||
SMOC-2 Antibody (F-11): m-IgG Fc BP-HRP Bundle | sc-525999 | 200 µg Ab; 10 µg BP | $361.00 | |||
SMOC-2 Antibody (F-11) AC | sc-376104 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SMOC-2 Antibody (F-11) HRP | sc-376104 HRP | 200 µg/ml | $322.00 | |||
SMOC-2 Antibody (F-11) FITC | sc-376104 FITC | 200 µg/ml | $336.00 | |||
SMOC-2 Antibody (F-11) PE | sc-376104 PE | 200 µg/ml | $349.00 | |||
SMOC-2 Antibody (F-11) Alexa Fluor® 488 | sc-376104 AF488 | 200 µg/ml | $364.00 | |||
SMOC-2 Antibody (F-11) Alexa Fluor® 546 | sc-376104 AF546 | 200 µg/ml | $364.00 | |||
SMOC-2 Antibody (F-11) Alexa Fluor® 594 | sc-376104 AF594 | 200 µg/ml | $364.00 | |||
SMOC-2 Antibody (F-11) Alexa Fluor® 647 | sc-376104 AF647 | 200 µg/ml | $364.00 | |||
SMOC-2 Antibody (F-11) Alexa Fluor® 680 | sc-376104 AF680 | 200 µg/ml | $364.00 | |||
SMOC-2 Antibody (F-11) Alexa Fluor® 790 | sc-376104 AF790 | 200 µg/ml | $364.00 |