SLM-2 Antibody (F-3): sc-374461

SLM-2 Antibody (F-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects SLM-2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). SLM-2 (F-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SLM-2 plays a crucial role in RNA binding and is part of the Sam68-like protein family, which is involved in regulating gene expression and cellular signaling pathways. SLM-2 is located predominantly in the nucleus, where SLM-2 participates in the post-transcriptional regulation of mRNA, influencing processes such as splicing and stability. Nuclear localization is essential for SLM-2 function, enabling interactions with RNA and other nuclear proteins to modulate gene expression in response to various cellular signals. Unlike Sam68, SLM-2 does not undergo tyrosine phosphorylation and does not appear to associate with key signaling proteins such as GRB2 and PLC gamma1, suggesting a distinct role in cellular signaling pathways. These unique characteristics make SLM-2 an important target for research into RNA metabolism and its implications in various diseases, including cancer and neurodegenerative disorders.

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SLM-2 Antibody (F-3) References:

1. Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis.  |  Di Fruscio, M., et al. 1999. Proc Natl Acad Sci U S A. 96: 2710-5. PMID: 10077576
2. A target for Src in mitosis.  |  Fumagalli, S., et al. 1994. Nature. 368: 871-4. PMID: 7512695
3. A protein that is highly related to GTPase-activating protein-associated p62 complexes with phospholipase C gamma.  |  Maa, MC., et al. 1994. Mol Cell Biol. 14: 5466-73. PMID: 7518563
4. Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1.  |  Richard, S., et al. 1995. Mol Cell Biol. 15: 186-97. PMID: 7799925
5. The human p62 cDNA encodes Sam68 and not the RasGAP-associated p62 protein.  |  Lock, P., et al. 1996. Cell. 84: 23-4. PMID: 8548822
6. Sam68 is a Ras-GAP-associated protein in mitosis.  |  Guitard, E., et al. 1998. Biochem Biophys Res Commun. 245: 562-6. PMID: 9571195

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SLM-2 Antibody (F-3) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-SLM-2 Antibody (F-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SLM-2 Antibody (F-3) Specifications

Alternate Product Name: SLM-2

Product Clone Name: F-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 305-341

Epitope Target: SLM-2

Epitope Species: mouse

Product Reactivity/Detection: SLM-2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for SLM-2 Antibody (F-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin