Slfn11 Antibody (E-4): sc-374339

Slfn11 Antibody (E-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects Slfn11 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Slfn11 antibody (E-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The Schlafen family, to which Slfn11 belongs, is primarily expressed in lymphoid tissues and plays a crucial role in regulating T cell development and function. Slfn11 (E-4) antibody targets a protein involved in suppressing cell growth and maintaining T cell quiescence, which is vital for preventing unwanted immune responses. Slfn11 is characterized by a conserved core domain, with significant diversification at the N terminus, which may influence functional interactions. Slfn11 expression is intricately linked to thymocyte maturation, and Slfn11 regulation can impact the phenotypic characteristics of thymic subsets. Understanding Slfn11 and its family members is essential for elucidating their roles in immune regulation and potential implications in autoimmune diseases and T cell-related disorders.

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Slfn11 Antibody (E-4) References:

1. T-cell development: a new marker of differentiation state.  |  Benoist, C. and Mathis, D. 1999. Curr Biol. 9: R59-61. PMID: 10021359
2. Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1.  |  Brady, G., et al. 2005. J Biol Chem. 280: 30723-34. PMID: 15946944
3. Subcellular localization of the Schlafen protein family.  |  Neumann, B., et al. 2008. Biochem Biophys Res Commun. 370: 62-6. PMID: 18355440
4. Schlafen 11 (SLFN11), a restriction factor for replicative stress induced by DNA-targeting anti-cancer therapies.  |  Murai, J., et al. 2019. Pharmacol Ther. 201: 94-102. PMID: 31128155
5. SLFN11 inhibits hepatocellular carcinoma tumorigenesis and metastasis by targeting RPS4X via mTOR pathway.  |  Zhou, C., et al. 2020. Theranostics. 10: 4627-4643. PMID: 32292519
6. Disruption of SLFN11 Deficiency-Induced CCL2 Signaling and Macrophage M2 Polarization Potentiates Anti-PD-1 Therapy Efficacy in Hepatocellular Carcinoma.  |  Zhou, C., et al. 2023. Gastroenterology. 164: 1261-1278. PMID: 36863689
7. Modulation of SLFN11 induces changes in DNA Damage response in breast cancer.  |  Raynaud, CM., et al. 2023. Cancer Cell Int. 23: 291. PMID: 38001424
8. Positive selection of thymocytes bearing alpha beta T cell receptors.  |  Marrack, P. and Kappler, J. 1997. Curr Opin Immunol. 9: 250-5. PMID: 9099796
9. Transgenic expression of a novel thymic epithelial cell antigen stimulates abberant development of thymocytes.  |  Takeuchi, T., et al. 1997. J Immunol. 159: 726-33. PMID: 9218588
10. Regulatory feedback pathways in the thymus.  |  Mehr, R., et al. 1997. Immunol Today. 18: 581-5. PMID: 9425736
11. In vitro thymocyte maturation is associated with reduced cellular susceptibility to Fas-mediated apoptosis.  |  Hershberger, PA., et al. 1998. Cell Immunol. 185: 134-45. PMID: 9636691
12. Schlafen, a new family of growth regulatory genes that affect thymocyte development.  |  Schwarz, DA., et al. 1998. Immunity. 9: 657-68. PMID: 9846487

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Slfn11 Antibody (E-4) has 24 citations in a variety of scientific publications.

Primary antibodies like Anti-Slfn11 Antibody (E-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Slfn11 Antibody (E-4) Specifications

Alternate Product Name: Schlafen Family Member 11

Product Clone Name: E-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 733-765

Epitope Target: Slfn11

Epitope Species: human

Product Reactivity/Detection: Slfn11

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 24 citations in various scientific publications

Available Conjugates/Forms for Slfn11 Antibody (E-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred Slfn11 antibody is Slfn11 Antibody (D-2): sc-515071.