SLC26A3 Antibody (H-8): sc-376187
- SLC26A3 Antibody (H-8) is a mouse monoclonal IgG1 κ SLC26A3 antibody, cited in 15 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 733-761 at the C-terminus of SLC26A3 of human origin
- SLC26A3 Antibody (H-8) is recommended for detection of SLC26A3 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-SLC26A3 Antibody (H-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SLC26A3 Antibody (H-8) for WB and IHC(P) applications. These reagents are now offered in bundles with SLC26A3 Antibody (H-8) (see ordering information below).
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SLC26A3 Antibody (H-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects SLC26A3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-SLC26A3 antibody (H-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SLC26A3 protein, also known as downregulated in adenoma, plays a crucial role as a chloride/bicarbonate exchanger primarily located in the epithelial cells of the colon, where SLC26A3 is essential for the absorption of electrolytes and fluids. This function is particularly important for maintaining fluid balance and electrolyte homeostasis in the gastrointestinal tract. SLC26A3 interacts with PDZK1, a scaffolding protein that aids in the localization and function of various transporters, thereby enhancing the efficiency of electrolyte absorption. Defects in SLC26A3 can lead to congenital chloride diarrhea, a condition characterized by severe electrolyte imbalances and dehydration. SLC26A3 monoclonal antibody (H-8) effectively detects SLC26A3 across multiple applications, making this reagent a valuable tool for researchers studying gastrointestinal physiology and related disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SLC26A3 Antibody (H-8) References:
- Identification of seven novel mutations including the first two genomic rearrangements in SLC26A3 mutated in congenital chloride diarrhea. | Höglund, P., et al. 2001. Hum Mutat. 18: 233-42. PMID: 11524734
- SLC26A3 mutations in congenital chloride diarrhea. | Mäkelä, S., et al. 2002. Hum Mutat. 20: 425-38. PMID: 12442266
- Acute regulation of the SLC26A3 congenital chloride diarrhoea anion exchanger (DRA) expressed in Xenopus oocytes. | Chernova, MN., et al. 2003. J Physiol. 549: 3-19. PMID: 12651923
- Clustering of private mutations in the congenital chloride diarrhea/down-regulated in adenoma gene. | Höglund, P., et al. 1998. Hum Mutat. 11: 321-7. PMID: 9554749
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SLC26A3 Antibody (H-8) | sc-376187 | 200 µg/ml | $322.00 | |||
SLC26A3 Antibody (H-8): m-IgG Fc BP-HRP Bundle | sc-529833 | 200 µg Ab; 10 µg BP | $361.00 | |||
SLC26A3 Antibody (H-8): m-IgGκ BP-HRP Bundle | sc-522868 | 200 µg Ab, 40 µg BP | $361.00 | |||
SLC26A3 Antibody (H-8): m-IgG1 BP-HRP Bundle | sc-543712 | 200 µg Ab; 20 µg BP | $361.00 | |||
SLC26A3 Antibody (H-8) AC | sc-376187 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SLC26A3 Antibody (H-8) HRP | sc-376187 HRP | 200 µg/ml | $322.00 | |||
SLC26A3 Antibody (H-8) FITC | sc-376187 FITC | 200 µg/ml | $336.00 | |||
SLC26A3 Antibody (H-8) PE | sc-376187 PE | 200 µg/ml | $349.00 | |||
SLC26A3 Antibody (H-8) Alexa Fluor® 488 | sc-376187 AF488 | 200 µg/ml | $364.00 | |||
SLC26A3 Antibody (H-8) Alexa Fluor® 546 | sc-376187 AF546 | 200 µg/ml | $364.00 | |||
SLC26A3 Antibody (H-8) Alexa Fluor® 594 | sc-376187 AF594 | 200 µg/ml | $364.00 | |||
SLC26A3 Antibody (H-8) Alexa Fluor® 647 | sc-376187 AF647 | 200 µg/ml | $364.00 | |||
SLC26A3 Antibody (H-8) Alexa Fluor® 680 | sc-376187 AF680 | 200 µg/ml | $364.00 | |||
SLC26A3 Antibody (H-8) Alexa Fluor® 790 | sc-376187 AF790 | 200 µg/ml | $364.00 | |||
SLC26A3 (H-8) Neutralizing Peptide | sc-376187 P | 100 µg/0.5 ml | $69.00 |