SLC25A11 Antibody (E-2): sc-515593
- SLC25A11 Antibody (E-2) is a mouse monoclonal IgG1 κ SLC25A11 antibody, cited in 6 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 142-159 within an internal region of SLC25A11 of human origin
- SLC25A11 Antibody (E-2) is recommended for detection of SLC25A11 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-SLC25A11 Antibody (E-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SLC25A11 Antibody (E-2) for WB applications. These reagents are now offered in bundles with SLC25A11 Antibody (E-2) (see ordering information below).
SLC25A11 Antibody (E-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects SLC25A11 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-SLC25A11 antibody (E-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SLC25A11, also known as the mitochondrial 2-oxoglutarate/malate carrier protein, plays a crucial role in cellular metabolism by facilitating the transport of 2-oxoglutarate across the inner mitochondrial membrane in exchange for dicarboxylic acids and malate. This transport is vital for maintaining the balance of metabolic intermediates and energy production within the mitochondria, as SLC25A11 is involved in key metabolic pathways such as the oxoglutarate/isocitrate shuttle and the malate-aspartate shuttle, which are essential for efficient cellular respiration and energy generation. Additionally, SLC25A11 contributes to nitrogen metabolism and gluconeogenesis from lactate, highlighting its importance in both energy production and metabolic regulation. SLC25A11 consists of 314 amino acids and features three solcar repeats, a characteristic structure of substrate carrier proteins that underscores its role in energy transfer within the cell.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SLC25A11 Antibody (E-2) References:
- Assignment of the oxoglutarate carrier gene (SLC20A4) to human chromosome 17p13.3. | Piccininni, S., et al. 1998. Cytogenet Cell Genet. 83: 256-7. PMID: 10072597
- Sequences of the human and bovine genes for the mitochondrial 2-oxoglutarate carrier. | Iacobazzi, V., et al. 1992. DNA Seq. 3: 79-88. PMID: 1457818
- The mitochondrial transporter family (SLC25): physiological and pathological implications. | Palmieri, F. 2004. Pflugers Arch. 447: 689-709. PMID: 14598172
- Solute carriers involved in energy transfer of mitochondria form a homologous protein family. | Aquila, H., et al. 1987. FEBS Lett. 212: 1-9. PMID: 3026849
- The mitochondrial carrier family of transport proteins: structural, functional, and evolutionary relationships. | Kuan, J. and Saier, MH. 1993. Crit Rev Biochem Mol Biol. 28: 209-33. PMID: 8325039
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SLC25A11 Antibody (E-2) | sc-515593 | 200 µg/ml | $316.00 | |||
SLC25A11 Antibody (E-2): m-IgG Fc BP-HRP Bundle | sc-531431 | 200 µg Ab; 10 µg BP | $354.00 | |||
SLC25A11 Antibody (E-2): m-IgGκ BP-HRP Bundle | sc-525119 | 200 µg Ab, 40 µg BP | $354.00 | |||
SLC25A11 Antibody (E-2): m-IgG1 BP-HRP Bundle | sc-544551 | 200 µg Ab; 20 µg BP | $354.00 | |||
SLC25A11 Antibody (E-2) AC | sc-515593 AC | 500 µg/ml, 25% agarose | $416.00 | |||
SLC25A11 Antibody (E-2) HRP | sc-515593 HRP | 200 µg/ml | $316.00 | |||
SLC25A11 Antibody (E-2) FITC | sc-515593 FITC | 200 µg/ml | $330.00 | |||
SLC25A11 Antibody (E-2) PE | sc-515593 PE | 200 µg/ml | $343.00 | |||
SLC25A11 Antibody (E-2) Alexa Fluor® 488 | sc-515593 AF488 | 200 µg/ml | $357.00 | |||
SLC25A11 Antibody (E-2) Alexa Fluor® 546 | sc-515593 AF546 | 200 µg/ml | $357.00 | |||
SLC25A11 Antibody (E-2) Alexa Fluor® 594 | sc-515593 AF594 | 200 µg/ml | $357.00 | |||
SLC25A11 Antibody (E-2) Alexa Fluor® 647 | sc-515593 AF647 | 200 µg/ml | $357.00 | |||
SLC25A11 Antibody (E-2) Alexa Fluor® 680 | sc-515593 AF680 | 200 µg/ml | $357.00 | |||
SLC25A11 Antibody (E-2) Alexa Fluor® 790 | sc-515593 AF790 | 200 µg/ml | $357.00 | |||
SLC25A11 (E-2) Neutralizing Peptide | sc-515593 P | 100 µg/0.5 ml | $68.00 |