SLAM Antibody (SLAM.4): sc-101620

SLAM Antibody (SLAM.4) is a mouse monoclonal IgG1 antibody that detects SLAM in human samples through applications such as immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). SLAM, or signaling lymphocyte-activation molecule, plays a crucial role in T cell activation and proliferation by providing a costimulatory signal that enhances T cell responses independently of CD28. This is particularly important in the immune response, as SLAM allows for a more robust activation of T cells in the presence of antigens, thereby contributing to effective immune surveillance and response. SLAM protein is primarily located on the surface of T cells, where SLAM interacts with ligands on antigen-presenting cells, facilitating communication between these cell types. This interaction is vital for the proper functioning of the immune system, as SLAM helps to regulate T cell expansion and cytokine production, which are essential for mounting an effective immune response. Additionally, mutations in the SLAM-associated protein (SAP), which interacts with SLAM, can lead to severe immunological disorders such as X-linked lymphoproliferative disease, highlighting the importance of this signaling pathway in maintaining immune homeostasis. Anti-SLAM antibody (SLAM.4) is an invaluable tool for researchers studying T cell biology and the underlying mechanisms of immune regulation.

The preferred SLAM antibody is SLAM Antibody (E-11): sc-166939.