SLA2 Antibody (E-8): sc-398134

SLA2 Antibody (E-8) is a mouse monoclonal IgG2b kappa light chain antibody that detects SLA2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SLA2 (E-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SLA2, also known as Src-like-adapter 2 or C20orf156, is a 261 amino acid protein that exists in four alternatively spliced isoforms, which can localize to either the cytoplasm or cell membrane and contain one SH2 domain and one SH3 domain. Predominantly expressed in immune system tissues such as thymus, spleen, and lymph nodes, SLA2 plays a crucial role as an adaptor protein that negatively regulates T-cell receptor signaling, thereby inhibiting T-cell activation. This regulation is vital for maintaining immune homeostasis and preventing overactive immune responses that could lead to autoimmune diseases. Additionally, SLA2 interacts with Zap-70, a key player in T-cell signaling, and is subject to post-translational phosphorylation, which can modulate activity and interactions. The gene encoding SLA2 is located on human chromosome 20, which comprises approximately 2% of the human genome and contains over 600 genes associated with various diseases, including Creutzfeldt-Jakob disease and amyotrophic lateral sclerosis.

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SLA2 Antibody (E-8) References:

1. Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling.  |  Holland, SJ., et al. 2001. J Exp Med. 194: 1263-76. PMID: 11696592
2. A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling.  |  Pandey, A., et al. 2002. J Biol Chem. 277: 19131-8. PMID: 11891219
3. Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling.  |  Loreto, MP., et al. 2002. Mol Cell Biol. 22: 4241-55. PMID: 12024036
4. Cloning and characterization of human Src-like adaptor protein 2 and a novel splice isoform, SLAP-2-v.  |  Loreto, MP. and McGlade, CJ. 2003. Oncogene. 22: 266-73. PMID: 12527895
5. Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner.  |  Dragone, LL., et al. 2006. Proc Natl Acad Sci U S A. 103: 18202-7. PMID: 17110436
6. The Src-like adaptor protein 2 regulates colony-stimulating factor-1 receptor signaling and down-regulation.  |  Pakuts, B., et al. 2007. J Biol Chem. 282: 17953-17963. PMID: 17353186

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SLA2 Antibody (E-8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-SLA2 Antibody (E-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SLA2 Antibody (E-8) Specifications

Alternate Product Name: SLA2

Product Clone Name: E-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 37-62

Epitope Target: SLA2

Epitope Species: human

Product Reactivity/Detection: SLA2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for SLA2 Antibody (E-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin