Siva Antibody (F-1): sc-376260

Siva Antibody (F-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects Siva protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-Siva antibody (F-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Siva protein plays a crucial role in apoptosis by interacting with the tumor necrosis factor receptor (TNFR) family member CD27, which is essential for mediating apoptotic signals. This interaction helps regulate immune responses and maintain homeostasis within the immune system. Siva protein contains a death domain that facilitates binding to CD27, thereby promoting apoptosis in activated T cells. Understanding Siva function in apoptosis is vital, as dysregulation of this process can lead to various diseases, including autoimmune disorders and cancer. Using Siva (F-1) antibody in research can provide insights into the mechanisms of apoptosis and Siva′s role in immune regulation, making this antibody an invaluable tool for studies focused on cell death and survival pathways.

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Siva Antibody (F-1) References:

1. The p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer Development.  |  Van Nostrand, JL., et al. 2015. Cancer Discov. 5: 622-35. PMID: 25813352
2. Siva plays a critical role in mouse embryonic development.  |  Jacobs, SBR., et al. 2020. Cell Death Differ. 27: 297-309. PMID: 31164717
3. FAIM-L - SIVA-1: Two Modulators of XIAP in Non-Apoptotic Caspase Function.  |  Coccia, E., et al. 2021. Front Cell Dev Biol. 9: 826037. PMID: 35083225
4. Concordance between SIVA, IVAN, and VAMPIRE Software Tools for Semi-Automated Analysis of Retinal Vessel Caliber.  |  Mautuit, T., et al. 2022. Diagnostics (Basel). 12: PMID: 35741127
5. SIVA-1 enhances acquired chemotherapeutic drug resistance of gastric cancer in vivo by regulating the ARF/MDM2/p53 pathway.  |  Wang, XT., et al. 2024. Heliyon. 10: e24394. PMID: 38312638
6. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis.  |  Chinnaiyan, AM., et al. 1995. Cell. 81: 505-12. PMID: 7538907
7. A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen.  |  Itoh, N. and Nagata, S. 1993. J Biol Chem. 268: 10932-7. PMID: 7684370
8. A novel domain within the 55 kd TNF receptor signals cell death.  |  Tartaglia, LA., et al. 1993. Cell. 74: 845-53. PMID: 8397073
9. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex.  |  Hsu, H., et al. 1996. Immunity. 4: 387-96. PMID: 8612133
10. Systematic mutational analysis of the death domain of the tumor necrosis factor receptor 1-associated protein TRADD.  |  Park, A. and Baichwal, VR. 1996. J Biol Chem. 271: 9858-62. PMID: 8621670
11. CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein.  |  Prasad, KV., et al. 1997. Proc Natl Acad Sci U S A. 94: 6346-51. PMID: 9177220
12. Caspases: the executioners of apoptosis.  |  Cohen, GM. 1997. Biochem J. 326 (Pt 1): 1-16. PMID: 9337844

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Siva Antibody (F-1) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-Siva Antibody (F-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Siva Antibody (F-1) Specifications

Alternate Product Name: Siva

Product Clone Name: F-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-175

Epitope Target: Siva

Epitope Species: mouse

Product Reactivity/Detection: Siva

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for Siva Antibody (F-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Siva antibody is Siva Antibody (H-9): sc-514375.