Sin Antibody (13): sc-136329

Sin Antibody (13) is a mouse monoclonal IgG1 kappa light chain antibody that detects Sin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). anti-Sin antibody (13) is available in both non-conjugated and various conjugated forms, including agarose and horseradish peroxidase (HRP). Sin protein, also known as Src interacting or signal integrating protein, plays a crucial role in cellular signaling pathways by interacting with several key proteins, including p130 Cas and Cas-L. These interactions are vital for mediating the effects of oncogenic tyrosine kinases, which are implicated in cancer progression. Sin contains SH2 and SH3 domains that facilitate binding to other signaling molecules, thereby influencing processes such as cell adhesion, migration, and proliferation. Sin′s ability to activate Src further underscores Sin′s importance in oncogenic signaling, making Sin a significant target for research in cancer biology. Sin monoclonal antibody (13) enables valuable insights into complex signaling networks that govern cellular behavior in various physiological and pathological contexts.

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Sin Antibody (13) References:

1. Tyrosine-phosphorylated epidermal growth factor receptor and cellular p130 provide high affinity binding substrates to analyze Crk-phosphotyrosine-dependent interactions in vitro.  |  Birge, RB., et al. 1992. J Biol Chem. 267: 10588-95. PMID: 1375224
2. Two species of human CRK cDNA encode proteins with distinct biological activities.  |  Matsuda, M., et al. 1992. Mol Cell Biol. 12: 3482-9. PMID: 1630456
3. Identification of domains of the v-crk oncogene product sufficient for association with phosphotyrosine-containing proteins.  |  Matsuda, M., et al. 1991. Mol Cell Biol. 11: 1607-13. PMID: 1705010
4. The SH2 and SH3 domains of pp60src direct stable association with tyrosine phosphorylated proteins p130 and p110.  |  Kanner, SB., et al. 1991. EMBO J. 10: 1689-98. PMID: 1710979
5. A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner.  |  Sakai, R., et al. 1994. EMBO J. 13: 3748-56. PMID: 8070403
6. Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin.  |  Alexandropoulos, K. and Baltimore, D. 1996. Genes Dev. 10: 1341-55. PMID: 8647432
7. Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae.  |  Law, SF., et al. 1996. Mol Cell Biol. 16: 3327-37. PMID: 8668148
8. Identification of an Efs isoform that lacks the SH3 domain and chromosomal mapping of human Efs.  |  Ishino, M., et al. 1997. Oncogene. 15: 1741-5. PMID: 9349509

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Sin Antibody (13) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Sin Antibody (13) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Sin Antibody (13) Specifications

Alternate Product Name: Sin

Product Clone Name: 13

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 142-258

Epitope Target: Sin

Epitope Species: mouse

Product Reactivity/Detection: Sin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Sin Antibody (13): AC: Agarose, HRP: Horseradish Peroxidase