SHOX2 Antibody (JK-6E): sc-81955

SHOX2 Antibody (JK-6E) is a mouse monoclonal IgG2a kappa light chain antibody that detects SHOX2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-SHOX2 antibody (JK-6E) is available as a non-conjugated format. SHOX2, also known as SHOT, is a crucial transcription factor belonging to the homeodomain protein family, which plays a significant role in regulating gene expression during development and differentiation. SHOX2 is characterized by a conserved 60-amino-acid homeodomain that allows binding to specific DNA sequences in the regulatory regions of target genes. SHOX2 exists in two isoforms, SHOX2A and SHOX2B, resulting from alternative splicing, which differ in their N-terminal residues and an alternatively spliced C-terminal exon. Both isoforms contain a C-terminal OAR domain, a motif particularly important for craniofacial development. Expression of the mouse ortholog, Og12X, has been identified in various tissues, including the aorta, female genitalia, and several regions of the developing brain, indicating involvement in critical developmental processes. Notably, aberrations in SHOX2 expression have been linked to Cornelia de Lange syndrome, a multisystem disorder characterized by developmental delays and distinct physical features, underscoring SHOX2′s importance in normal development and potential implications in genetic disorders.

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SHOX2 Antibody (JK-6E) References:

1. The homeodomain-containing proteins: an update on their interacting partners.  |  Chariot, A., et al. 1999. Biochem Pharmacol. 58: 1851-7. PMID: 10591139
2. SHOX in short stature syndromes.  |  Blaschke, RJ. and Rappold, GA. 2001. Horm Res. 55 Suppl 1: 21-3. PMID: 11408757
3. Dominant paternal transmission of Cornelia de Lange syndrome: a new case and review of 25 previously reported familial recurrences.  |  Russell, KL., et al. 2001. Am J Med Genet. 104: 267-76. PMID: 11754058
4. Transcriptional and translational regulation of the Leri-Weill and Turner syndrome homeobox gene SHOX.  |  Blaschke, RJ., et al. 2003. J Biol Chem. 278: 47820-6. PMID: 12960152
5. The short stature homeodomain protein SHOX induces cellular growth arrest and apoptosis and is expressed in human growth plate chondrocytes.  |  Marchini, A., et al. 2004. J Biol Chem. 279: 37103-14. PMID: 15145945
6. Diagnosis of Lung Cancer by SHOX2 Gene Methylation Assay.  |  Song, L., et al. 2015. Mol Diagn Ther. 19: 159-67. PMID: 26014676
7. Signaling pathways and clinical application of RASSF1A and SHOX2 in lung cancer.  |  Li, N., et al. 2020. J Cancer Res Clin Oncol. 146: 1379-1393. PMID: 32266538
8. SHOX2 refines the identification of human sinoatrial nodal cell population in the in vitro cardiac differentiation.  |  Wakimizu, T., et al. 2022. Regen Ther. 21: 239-249. PMID: 36092505
9. A potential immunotherapeutic and prognostic biomarker for multiple tumors including glioma: SHOX2.  |  Wu, X., et al. 2023. Hereditas. 160: 21. PMID: 37170390
10. SHOX2 promotes prostate cancer proliferation and metastasis through disruption of the Hippo-YAP pathway.  |  Yang, W., et al. 2023. iScience. 26: 107617. PMID: 37664594
11. A new human homeobox gene OGI2X is a member of the most conserved homeobox gene family and is expressed during heart development in mouse.  |  Semina, EV., et al. 1998. Hum Mol Genet. 7: 415-22. PMID: 9466998
12. SHOT, a SHOX-related homeobox gene, is implicated in craniofacial, brain, heart, and limb development.  |  Blaschke, RJ., et al. 1998. Proc Natl Acad Sci U S A. 95: 2406-11. PMID: 9482898

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SHOX2 Antibody (JK-6E) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-SHOX2 Antibody (JK-6E) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SHOX2 Antibody (JK-6E) Specifications

Alternate Product Name: SHOX2

Product Clone Name: JK-6E

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 117-205

Epitope Target: SHOX2

Epitope Species: human

Product Reactivity/Detection: SHOX2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for SHOX2 Antibody (JK-6E): N/A