SHIP-1 Antibody (P1C1): sc-8425
- SHIP-1 Antibody (P1C1) is a mouse monoclonal IgG1 κ SHIP-1 antibody, cited in 141 publications, provided at 200 µg/ml
- raised against amino acids 866-1020 mapping at the C-terminus of SHIP-1 of mouse origin
- SHIP-1 Antibody (P1C1) is recommended for detection of SHIP-1 p145 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-SHIP-1 Antibody (P1C1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SHIP-1 Antibody (P1C1) for WB and IHC(P) applications. These reagents are now offered in bundles with SHIP-1 Antibody (P1C1) (see ordering information below).
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SHIP-1 Antibody (P1C1) is a mouse monoclonal IgG1 kappa light chain antibody designed to detect SHIP-1, also known as INPP5D, in mouse, rat, and human samples. SHIP-1, an SH2-containing inositol 5-phosphatase, is a critical regulator of the PI3K signaling pathway. By dephosphorylating phosphatidylinositol-3,4,5-trisphosphate (PIP3) into phosphatidylinositol-4,5-bisphosphate (PIP2), SHIP-1 attenuates signaling cascades involved in immune cell activation, proliferation, and survival. This negative regulation is essential for maintaining immune homeostasis and protecting against hyperactivation that can lead to inflammatory or autoimmune disorders. SHIP-1 is primarily expressed in hematopoietic cells and is implicated in key processes such as hematopoiesis, mast cell degranulation, and B cell receptor signaling. SHIP-1 monoclonal antibody (P1C1) targets a highly conserved C-terminal epitope encompassing amino acids 866–1020 in applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). SHIP-1 monoclonal antibody (P1C1) is available in non-conjugated and conjugated forms, such as horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and Alexa Fluor® variants. SHIP-1 monoclonal antibody (P1C1) is recommended for research studying signal transduction, immune cell regulation, and hematopoietic development.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SHIP-1 Antibody (P1C1) References:
- Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. | Matsushime, H., et al. 1991. Cell. 65: 701-13. PMID: 1827757
- The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1. | Sherr, CJ., et al. 1985. Cell. 41: 665-76. PMID: 2408759
- Transforming potential of the c-fms proto-oncogene (CSF-1 receptor). | Roussel, MF., et al. Nature. 325: 549-52. PMID: 3027579
- Chromosomal localization of the human c-fms oncogene. | Groffen, J., et al. 1983. Nucleic Acids Res. 11: 6331-9. PMID: 6684766
- The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase. | Damen, JE., et al. 1996. Proc Natl Acad Sci U S A. 93: 1689-93. PMID: 8643691
- p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity. | Lioubin, MN., et al. 1996. Genes Dev. 10: 1084-95. PMID: 8654924
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SHIP-1 Antibody (P1C1) | sc-8425 | 200 µg/ml | $322.00 | |||
SHIP-1 Antibody (P1C1): m-IgG Fc BP-HRP Bundle | sc-528229 | 200 µg Ab; 10 µg BP | $361.00 | |||
SHIP-1 Antibody (P1C1): m-IgGκ BP-HRP Bundle | sc-520555 | 200 µg Ab, 40 µg BP | $361.00 | |||
SHIP-1 Antibody (P1C1): m-IgG1 BP-HRP Bundle | sc-542828 | 200 µg Ab; 20 µg BP | $361.00 | |||
SHIP-1 Antibody (P1C1) AC | sc-8425 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SHIP-1 Antibody (P1C1) HRP | sc-8425 HRP | 200 µg/ml | $322.00 | |||
SHIP-1 Antibody (P1C1) FITC | sc-8425 FITC | 200 µg/ml | $336.00 | |||
SHIP-1 Antibody (P1C1) PE | sc-8425 PE | 200 µg/ml | $349.00 | |||
SHIP-1 Antibody (P1C1) Alexa Fluor® 488 | sc-8425 AF488 | 200 µg/ml | $364.00 | |||
SHIP-1 Antibody (P1C1) Alexa Fluor® 546 | sc-8425 AF546 | 200 µg/ml | $364.00 | |||
SHIP-1 Antibody (P1C1) Alexa Fluor® 594 | sc-8425 AF594 | 200 µg/ml | $364.00 | |||
SHIP-1 Antibody (P1C1) Alexa Fluor® 647 | sc-8425 AF647 | 200 µg/ml | $364.00 | |||
SHIP-1 Antibody (P1C1) Alexa Fluor® 680 | sc-8425 AF680 | 200 µg/ml | $364.00 | |||
SHIP-1 Antibody (P1C1) Alexa Fluor® 790 | sc-8425 AF790 | 200 µg/ml | $364.00 |