SHIP-1 Antibody (E-8): sc-393361
- SHIP-1 Antibody (E-8) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1161-1188 at the C-terminus of SHIP of mouse origin
- recommended for detection of SHIP-1 p145 of mouse origin by WB, IP, IF and ELISA
- See SHIP-1 (P1C1): sc-8425 for SHIP-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SHIP-1 Antibody (E-8) for WB applications. These reagents are now offered in bundles with SHIP-1 Antibody (E-8) (see ordering information below).
SHIP-1 Antibody (E-8) is a mouse monoclonal IgG1 kappa light chain antibody designed to detect SHIP-1, also known as INPP5D, exclusively in mouse species. SHIP-1 is a critical SH2-containing inositol phosphatase that plays a pivotal role in the negative regulation of the PI3K signaling pathway by dephosphorylating PIP3 to PIP2, thereby modulating key cellular processes such as immune cell activation, proliferation, and survival. This regulation is essential for maintaining immune homeostasis and preventing aberrant immune responses that can lead to autoimmune diseases and cancer. SHIP-1 (E-8) monoclonal antibody specifically recognizes an epitope mapping between amino acids 1161-1188 at the C-terminus of SHIP-1, ensuring high specificity and reliable performance in applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SHIP-1 undergoes several post-translational modifications, including phosphorylation and ubiquitination, which are crucial for its regulation and interaction with other signaling molecules. These modifications influence SHIP-1′s stability, localization, and activity, making the detection of its specific epitopes vital for understanding its functional mechanisms. By accurately identifying SHIP-1 p145 in mouse models, anti-SHIP-1 antibody (E-8) serves as an invaluable tool for researchers studying signal transduction, hematopoiesis, and immune responses. SHIP-1 (E-8) monoclonal antibody provides consistent and precise results, advancing the understanding of SHIP-1 mediated pathways and their implications in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SHIP-1 Antibody (E-8) | sc-393361 | 200 µg/ml | $322.00 | |||
SHIP-1 Antibody (E-8): m-IgG Fc BP-HRP Bundle | sc-538194 | 200 µg Ab; 10 µg BP | $361.00 | |||
SHIP-1 Antibody (E-8): m-IgGκ BP-HRP Bundle | sc-535761 | 200 µg Ab; 40 µg BP | $361.00 | |||
SHIP-1 Antibody (E-8): m-IgG1 BP-HRP Bundle | sc-545569 | 200 µg Ab; 20 µg BP | $361.00 | |||
SHIP-1 (E-8) Neutralizing Peptide | sc-393361 P | 100 µg/0.5 ml | $69.00 |