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SH3D19 Antibody (G-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects SH3D19 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-SH3D19 antibody (G-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SH3D19, also known as SH3 domain-containing protein 19, EBP, EEN-binding protein, EVE1, or Kryn, is a 790 amino acid protein widely expressed, with highest levels found in kidney, heart, lung, liver, skeletal muscle, and small intestine. SH3D19 primarily localizes in cytoplasm but can be recruited to nucleus by a fusion protein known as MLL-EEN (mixed-lineage leukemia-endophilin), highlighting potential role in cellular signaling pathways. SH3D19 regulates ADAM (A disintegrin and metalloproteases) proteins in epidermal growth factor receptor-ligand shedding pathways, crucial for various physiological processes, including cell proliferation and differentiation. SH3D19 contains five SH3 domains, important for protein-protein interactions, and may suppress Ras-induced cellular transformation and activation of downstream signaling proteins such as Elk-1. Translocation events involving SH3D19 have been implicated in acute myeloid leukemia, suggesting a significant role in carcinogenesis. Alternative splicing of SH3D19 results in expression of five distinct isoforms, adding complexity to functional repertoire in cellular processes.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SH3D19 Antibody (G-6) | sc-377282 | 200 µg/ml | $316.00 | |||
SH3D19 Antibody (G-6): m-IgG Fc BP-HRP Bundle | sc-530000 | 200 µg Ab; 10 µg BP | $354.00 | |||
SH3D19 Antibody (G-6): m-IgGκ BP-HRP Bundle | sc-523264 | 200 µg Ab, 40 µg BP | $354.00 | |||
SH3D19 Antibody (G-6): m-IgG1 BP-HRP Bundle | sc-543812 | 200 µg Ab; 20 µg BP | $354.00 | |||
SH3D19 Antibody (G-6) AC | sc-377282 AC | 500 µg/ml, 25% agarose | $416.00 | |||
SH3D19 Antibody (G-6) HRP | sc-377282 HRP | 200 µg/ml | $316.00 | |||
SH3D19 Antibody (G-6) FITC | sc-377282 FITC | 200 µg/ml | $330.00 | |||
SH3D19 Antibody (G-6) PE | sc-377282 PE | 200 µg/ml | $343.00 | |||
SH3D19 Antibody (G-6) Alexa Fluor® 488 | sc-377282 AF488 | 200 µg/ml | $357.00 | |||
SH3D19 Antibody (G-6) Alexa Fluor® 546 | sc-377282 AF546 | 200 µg/ml | $357.00 | |||
SH3D19 Antibody (G-6) Alexa Fluor® 594 | sc-377282 AF594 | 200 µg/ml | $357.00 | |||
SH3D19 Antibody (G-6) Alexa Fluor® 647 | sc-377282 AF647 | 200 µg/ml | $357.00 | |||
SH3D19 Antibody (G-6) Alexa Fluor® 680 | sc-377282 AF680 | 200 µg/ml | $357.00 | |||
SH3D19 Antibody (G-6) Alexa Fluor® 790 | sc-377282 AF790 | 200 µg/ml | $357.00 |