SH2D4A Antibody (63-J): sc-100288
- SH2D4A Antibody (63-J) is a mouse monoclonal IgG2a κ provided at 100 µg/ml
- raised against recombinant SH2D4A of human origin
- recommended for detection of SH2D4A of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SH2D4A Antibody (63-J). This work is in progress.
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SH2D4A Antibody (63-J) is a mouse monoclonal IgG2a antibody that detects SH2D4A in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). SH2D4A, also known as SH2A, is a 454 amino acid docking protein that is widely expressed and belongs to the SH2 signaling protein family, which plays a crucial role in intracellular signaling pathways. SH2D4A is primarily localized in the cytoplasm and contains a single Src homology 2 (SH2) domain, which is essential for binding to tyrosine-phosphorylated regions of target proteins. The ability of SH2D4A to interact with these phosphorylated sites suggests a significant role in linking activated growth factors to downstream signaling proteins, thereby influencing cellular responses. Notably, SH2D4A acts as an inhibitory factor in protein kinase C (PKC) signal transduction, highlighting its importance in regulating cellular signaling pathways. Furthermore, aberrant expression of SH2D4A has been observed in various cancers, indicating potential involvement in tumorigenesis and making SH2D4A a valuable target for cancer research.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SH2D4A Antibody (63-J) | sc-100288 | 100 µg/ml | $339.00 |