SgK223 Antibody (O67): sc-130491
- SgK223 Antibody (O67) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant Pragmin of human origin
- recommended for detection of SgK223 of human origin by IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SgK223 Antibody (O67). This work is in progress.
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SgK223 Antibody (O67) is a mouse monoclonal IgG2a antibody that detects SgK223 in human samples through immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP). SgK223, also known as Sugen kinase 223, plays a crucial role in cellular signaling pathways, particularly in RhoA activity regulation, which is essential for various cellular processes including cell contraction and neurite outgrowth. SgK223 is primarily located in the cytoplasm and interacts with Rnd2 in a GTP-dependent manner, thereby influencing the actin cytoskeleton and cell adhesion dynamics. This interaction is vital for maintaining proper cellular morphology and function, as dysregulation can lead to impaired neuronal development and contribute to various pathologies. SgK223′s ability to stimulate RhoA activity highlights SgK223′s importance in modulating cytoskeletal organization, making SgK223 a significant target for research in neurobiology and cancer studies. Anti-SgK223 antibody (O67) is an invaluable tool for researchers aiming to explore the intricate roles of SgK223 in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SgK223 Antibody (O67) | sc-130491 | 100 µg/ml | $339.00 |