Date published: 2025-10-25

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SgK223 Activators

SgK223 activators encompass a diverse array of chemical compounds that indirectly enhance the functional activity of SgK223 through discrete signaling pathways. Forskolin, by raising cAMP levels, indirectly promotes SgK223-mediated cellular migration by activating PKA, which phosphorylates proteins that can interact with SgK223. Similarly, PMA, through the activation of PKC, can lead to the phosphorylation of proteins that are part of the SgK223 signaling cascade, thereby enhancing its role in cellular adhesion. The calcium ionophore Ionomycin raises intracellular calcium, potentially activating pathways that converge on SgK223, enhancing its role in calcium-dependent signaling. Growth factors such as EGF stimulate their respective receptors to initiate signaling cascades that culminate in the upregulation of SgK223 activity, thereby promoting cellular proliferation and differentiation.

Additionally, metabolic regulators like insulin can enhance SgK223 activity via PI3K/Akt signaling. The paradoxical use of LY294002, a PI3K inhibitor, may allow for the compensatory activation of SgK223-associated pathways. Inhibitors of MAPK signaling, such as SB203580 and U0126, shift the signaling balance to enhance SgK223's participation in cellular stress responses and proliferation processes. Phosphatase inhibitors Calyculin A and Okadaic acid increase phosphorylation states within SgK223 pathways, augmenting its activity in cellular growth and motility. The polyamine Spermine enhances SgK223's involvement in the regulation of growth and differentiation by modulating ion channels and second messengers. Anisomycin, through the activation of stress-activated protein kinases, indirectly supports SgK223 activity linked to the cellular response to stress, rounding off the suite of chemical activators that, by influencing specific signaling events, enhance the functional activity of SgK223 without directly increasing its expression or requiring direct activation.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$76.00
$150.00
$725.00
$1385.00
$2050.00
73
(3)

Forskolin activates adenylate cyclase, leading to an increase in cAMP levels which can enhance the activity of SgK223 by promoting downstream signaling involved in cytoskeletal organization and cellular migration.

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$40.00
$129.00
$210.00
$490.00
$929.00
119
(6)

PMA activates protein kinase C (PKC), which can phosphorylate substrates that interact with SgK223, thereby enhancing its activity related to cellular adhesion and migration.

Ionomycin

56092-82-1sc-3592
sc-3592A
1 mg
5 mg
$76.00
$265.00
80
(4)

Ionomycin serves as a calcium ionophore, raising intracellular calcium levels which can activate calcineurin or other calcium-dependent kinases that subsequently increase SgK223 activity related to calcium signaling pathways.

Insulin

11061-68-0sc-29062
sc-29062A
sc-29062B
100 mg
1 g
10 g
$153.00
$1224.00
$12239.00
82
(1)

Insulin activates the PI3K/Akt pathway, which can enhance SgK223 activity by stimulating pathways that promote cell survival and metabolism, processes in which SgK223 has a role.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

LY294002 is a PI3K inhibitor that can paradoxically enhance SgK223 activity by reducing negative feedback loops in PI3K signaling, thereby allowing for the compensatory activation of SgK223-related pathways.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$88.00
$342.00
284
(5)

SB203580 is a p38 MAPK inhibitor that may enhance SgK223 activity by shifting the balance of cellular signaling towards pathways involving SgK223, particularly in stress response.

Calyculin A

101932-71-2sc-24000
sc-24000A
sc-24000B
sc-24000C
10 µg
100 µg
500 µg
1 mg
$160.00
$750.00
$1400.00
$3000.00
59
(3)

Calyculin A inhibits protein phosphatases 1 and 2A, leading to an increase in phosphorylation levels of proteins that could enhance the activity of SgK223 in signal transduction pathways.

Okadaic Acid

78111-17-8sc-3513
sc-3513A
sc-3513B
25 µg
100 µg
1 mg
$285.00
$520.00
$1300.00
78
(4)

Okadaic acid, a potent inhibitor of protein phosphatases, can increase the phosphorylation state of proteins within SgK223 pathways, enhancing its activity in cellular processes such as growth and motility.

Spermine

71-44-3sc-212953A
sc-212953
sc-212953B
sc-212953C
1 g
5 g
25 g
100 g
$60.00
$192.00
$272.00
$883.00
1
(0)

Spermine can modulate ion channel activity and second messenger systems, potentially enhancing SgK223's role in cellular signaling pathways that regulate growth and differentiation.

Anisomycin

22862-76-6sc-3524
sc-3524A
5 mg
50 mg
$97.00
$254.00
36
(2)

Anisomycin acts as a protein synthesis inhibitor, which can lead to the activation of stress-activated protein kinases, indirectly enhancing SgK223 activity that is associated with cellular stress responses.