Sg II Antibody (SGII 9G3/3): sc-53441

Sg II Antibody (SGII 9G3/3) is a mouse monoclonal IgG2b kappa light chain antibody that detects Sg II protein of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Anti-Sg II antibody (SGII 9G3/3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Sg II protein, a member of the chromogranin family, plays a crucial role in the storage and release of neuropeptides and hormones within secretory granules of neuroendocrine and endocrine cells. Sg II localization within these granules is vital for the regulated secretion of bioactive molecules, which are essential for various physiological processes, including the modulation of insulin secretion and the regulation of blood pressure. Notably, Sg II levels can significantly increase in response to stimuli such as histamine, highlighting Sg II importance in neuroendocrine signaling. Sg II interaction with cholesterol-rich secretory granule membranes further underscores Sg II role in the dynamics of hormone release, making Sg II a key player in the endocrine system′s functionality.

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Sg II Antibody (SGII 9G3/3) References:

1. Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic beta-cells.  |  Hosaka, M., et al. 2002. Mol Biol Cell. 13: 3388-99. PMID: 12388744
2. Immunocytochemical localization of secretogranin III in the anterior lobe of male rat pituitary glands.  |  Sakai, Y., et al. 2003. J Histochem Cytochem. 51: 227-38. PMID: 12533531
3. Immunolocalization of secretogranin II, chromogranin A, and chromogranin B in differentiating human neuroblastoma cells.  |  Giudici, AM., et al. 1992. Eur J Cell Biol. 58: 383-9. PMID: 1425774
4. Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A.  |  Hosaka, M., et al. 2004. J Biol Chem. 279: 3627-34. PMID: 14597614
5. Interaction between secretogranin III and carboxypeptidase E facilitates prohormone sorting within secretory granules.  |  Hosaka, M., et al. 2005. J Cell Sci. 118: 4785-95. PMID: 16219686
6. Measurements of chromogranin A, chromogranin B (secretogranin I), chromogranin C (secretogranin II) and pancreastatin in plasma and urine from patients with carcinoid tumours and endocrine pancreatic tumours.  |  Stridsberg, M., et al. 1995. J Endocrinol. 144: 49-59. PMID: 7891024
7. Immunohistochemical demonstration of chromogranin A, chromogranin B, and secretogranin II in extra-adrenal paragangliomas.  |  Schmid, KW., et al. 1994. Mod Pathol. 7: 347-53. PMID: 8058707
8. Current status on chromogranin A and pancreastatin.  |  Robberecht, P., et al. 1993. Acta Gastroenterol Belg. 56: 261-3. PMID: 8266767
9. Chromogranin A, secretogranin II and vasoactive intestinal peptide in phaeochromocytomas and ganglioneuromas.  |  Schmid, KW., et al. 1993. Histopathology. 22: 527-33. PMID: 8354485
10. Histamine induces a gene-specific synthesis regulation of secretogranin II but not of chromogranin A and B in chromaffin cells in a calcium-dependent manner.  |  Bauer, JW., et al. 1993. J Biol Chem. 268: 1586-9. PMID: 8420933

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Sg II Antibody (SGII 9G3/3) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-Sg II Antibody (SGII 9G3/3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Sg II Antibody (SGII 9G3/3) Specifications

Alternate Product Name: Sg II

Product Clone Name: SGII 9G3/3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids:

Epitope Target: Sg II

Epitope Species: rat

Product Reactivity/Detection: secretogranin II

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for Sg II Antibody (SGII 9G3/3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin