SerpinB8 Antibody (PI-8): sc-101371
- SerpinB8 Antibody (PI-8) is a mouse monoclonal IgG1 κ SerpinB8 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against SerpinB8 of human origin
- SerpinB8 Antibody (PI-8) is recommended for detection of SerpinB8 of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-SerpinB8 Antibody (PI-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for SerpinB8 Antibody (PI-8) for WB and IHC(P) applications. These reagents are now offered in bundles with SerpinB8 Antibody (PI-8) (see ordering information below).
SerpinB8 Antibody (PI-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects SerpinB8 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-SerpinB8 antibody (PI-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SerpinB8, also known as P18 or CAP2, is a 374 amino acid protein that plays a crucial role in regulating platelet aggregation and modulating pathophysiological responses related to hemostasis and inflammation. Located primarily in the cytoplasm, SerpinB8 is expressed at high levels in vital tissues such as the lung, liver, heart, and skeletal muscle, highlighting its importance in various physiological processes. SerpinB8 belongs to the serine proteinase inhibitor family, which is essential for controlling proteolytic activity in the body, thereby influencing blood coagulation, complement activation, and tissue development. The gene encoding SerpinB8 is situated on human chromosome 18, a region that contains a cluster of serpin genes, underscoring the evolutionary significance and functional diversity of this protein family.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SerpinB8 Antibody (PI-8) References:
- Distribution of the human intracellular serpin protease inhibitor 8 in human tissues. | Strik, MC., et al. 2002. J Histochem Cytochem. 50: 1443-54. PMID: 12417609
- Control of the coagulation system by serpins. Getting by with a little help from glycosaminoglycans. | Pike, RN., et al. 2005. FEBS J. 272: 4842-51. PMID: 16176258
- The serpin proteinase inhibitor 8: an endogenous furin inhibitor released from human platelets. | Leblond, J., et al. 2006. Thromb Haemost. 95: 243-52. PMID: 16493485
- Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins. | Huber, R. and Carrell, RW. 1989. Biochemistry. 28: 8951-66. PMID: 2690952
- Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors. | Sprecher, CA., et al. 1995. J Biol Chem. 270: 29854-61. PMID: 8530382
- Cytoplasmic antiproteinase 2 (PI8) and bomapin (PI10) map to the serpin cluster at 18q21.3. | Bartuski, AJ., et al. 1997. Genomics. 43: 321-8. PMID: 9268635
- Inhibition of soluble recombinant furin by human proteinase inhibitor 8. | Dahlen, JR., et al. 1998. J Biol Chem. 273: 1851-4. PMID: 9442015
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SerpinB8 Antibody (PI-8) | sc-101371 | 200 µg/ml | $322.00 | |||
SerpinB8 Antibody (PI-8): m-IgG Fc BP-HRP Bundle | sc-527066 | 200 µg Ab; 10 µg BP | $361.00 | |||
SerpinB8 Antibody (PI-8): m-IgG1 BP-HRP Bundle | sc-532439 | 200 µg Ab; 20 µg BP | $361.00 | |||
SerpinB8 Antibody (PI-8) AC | sc-101371 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SerpinB8 Antibody (PI-8) HRP | sc-101371 HRP | 200 µg/ml | $322.00 | |||
SerpinB8 Antibody (PI-8) FITC | sc-101371 FITC | 200 µg/ml | $336.00 | |||
SerpinB8 Antibody (PI-8) PE | sc-101371 PE | 200 µg/ml | $349.00 | |||
SerpinB8 Antibody (PI-8) Alexa Fluor® 488 | sc-101371 AF488 | 200 µg/ml | $364.00 | |||
SerpinB8 Antibody (PI-8) Alexa Fluor® 546 | sc-101371 AF546 | 200 µg/ml | $364.00 | |||
SerpinB8 Antibody (PI-8) Alexa Fluor® 594 | sc-101371 AF594 | 200 µg/ml | $364.00 | |||
SerpinB8 Antibody (PI-8) Alexa Fluor® 647 | sc-101371 AF647 | 200 µg/ml | $364.00 | |||
SerpinB8 Antibody (PI-8) Alexa Fluor® 680 | sc-101371 AF680 | 200 µg/ml | $364.00 | |||
SerpinB8 Antibody (PI-8) Alexa Fluor® 790 | sc-101371 AF790 | 200 µg/ml | $364.00 |