SerpinB6 Antibody (E-8): sc-398487

SerpinB6 Antibody (E-8) is a mouse monoclonal IgM antibody that detects SerpinB6 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-SerpinB6 antibody (E-8) is available as a non-conjugated format. SerpinB6, also known as protease inhibitor 6 (PI-6) in humans and Spi3 in mice, is a crucial serine protease inhibitor that plays a significant role in regulating proteolytic activity within the cytoplasm. Unlike many serpins that are secreted and function extracellularly, SerpinB6 is primarily localized in the cytoplasm, where SerpinB6 forms stable complexes with target proteases, such as human kallikrein 2 (hK2) and cathepsin G, which are important for various physiological processes including inflammation and tissue remodeling. The cytoplasmic localization of SerpinB6 is particularly important as SerpinB6 allows for the regulation of protease activity in response to cellular signals, thereby influencing cellular responses to stress and injury. Additionally, SerpinB6 is expressed in a variety of human tissues, including capillary endothelial cells, platelets, epithelial cells, monocytes, and granulocytes, highlighting SerpinB6′s potential role in diverse biological functions. With an ability to inhibit specific proteases, SerpinB6 is a key player in maintaining homeostasis and protecting tissues from excessive proteolytic damage, making SerpinB6 a valuable target for research in various fields, including cancer and inflammatory diseases.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SerpinB6 Antibody (E-8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-SerpinB6 Antibody (E-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SerpinB6 Antibody (E-8) Specifications

Alternate Product Name: SerpinB6

Product Clone Name: E-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 178-193

Epitope Target: SerpinB6

Epitope Species: human

Product Reactivity/Detection: SerpinB6

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for SerpinB6 Antibody (E-8): P: Blocking Peptide

The preferred SerpinB6 antibody is SerpinB6 Antibody (F-5): sc-374535.