Serine racemase Antibody (A-4): sc-365217

Serine racemase Antibody (A-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects Serine racemase protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Serine racemase antibody (A-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Serine racemase (A-4) monoclonal antibody plays a crucial role in studying the central nervous system by detecting proteins that catalyze the conversion of L-serine to D-serine, a significant endogenous co-agonist of N-methyl-D-aspartate (NMDA) receptors, which are essential for synaptic plasticity, learning, and memory. The presence of D-serine in the mammalian brain highlights its importance in neurotransmission and neurodevelopment, as well as its involvement in neurodegenerative diseases. Additionally, Serine racemase (A-4) antibody helps identify proteins predominantly localized in glial cells, which are vital for maintaining the homeostasis of the brain environment and supporting neuronal function. Understanding the dynamics of D-serine and its synthesis by serine racemase can provide insights into various neurological disorders and potential therapeutic targets.

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Serine racemase Antibody (A-4) References:

1. Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission.  |  Wolosker, H., et al. 1999. Proc Natl Acad Sci U S A. 96: 13409-14. PMID: 10557334
2. Characterization and localization of a human serine racemase.  |  Xia, M., et al. 2004. Brain Res Mol Brain Res. 125: 96-104. PMID: 15193426
3. Schwann cell and epineural fibroblast expression of serine racemase.  |  Wu, S., et al. 2004. Brain Res. 1020: 161-6. PMID: 15312798
4. Induction of serine racemase by inflammatory stimuli is dependent on AP-1.  |  Wu, S. and Barger, SW. 2004. Ann N Y Acad Sci. 1035: 133-46. PMID: 15681805
5. Potential roles of D-serine and serine racemase in experimental temporal lobe epilepsy.  |  Ryu, HJ., et al. 2010. J Neurosci Res. 88: 2469-82. PMID: 20623543
6. Loss-of-function mutation of serine racemase attenuates retinal ganglion cell loss in diabetic mice.  |  Jiang, H., et al. 2018. Exp Eye Res. 175: 90-97. PMID: 29913163
7. The origin of NMDA receptor hypofunction in schizophrenia.  |  Nakazawa, K. and Sapkota, K. 2020. Pharmacol Ther. 205: 107426. PMID: 31629007
8. Effects of Topic Delivery of an Inhibitor of Serine Racemase on Laser-Induced Choroidal Vasculopathy.  |  Wang, S., et al. 2024. Transl Vis Sci Technol. 13: 24. PMID: 39136959
9. Free D-serine in post-mortem brains and spinal cords of individuals with and without neuropsychiatric diseases.  |  Kumashiro, S., et al. 1995. Brain Res. 681: 117-25. PMID: 7552268
10. D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release.  |  Schell, MJ., et al. 1995. Proc Natl Acad Sci U S A. 92: 3948-52. PMID: 7732010
11. Free D-serine, D-aspartate and D-alanine in central nervous system and serum in mutant mice lacking D-amino acid oxidase.  |  Hashimoto, A., et al. 1993. Neurosci Lett. 152: 33-6. PMID: 8100053
12. Purification of serine racemase: biosynthesis of the neuromodulator D-serine.  |  Wolosker, H., et al. 1999. Proc Natl Acad Sci U S A. 96: 721-5. PMID: 9892700

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Serine racemase Antibody (A-4) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-Serine racemase Antibody (A-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Serine racemase Antibody (A-4) Specifications

Alternate Product Name: Serine racemase

Product Clone Name: A-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 191-340

Epitope Target: Serine racemase

Epitope Species: human

Product Reactivity/Detection: Serine racemase

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for Serine racemase Antibody (A-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin