Serine racemase Inhibitors
Serine racemase inhibitors comprise a diverse group of chemicals that modulate the enzymatic activity of serine racemase, influencing pathways related to glutamate regulation. L-DOPA, a dopamine precursor, indirectly impacts serine racemase by altering dopaminergic signaling, potentially affecting downstream pathways. Fluoxetine, a selective serotonin reuptake inhibitor, influences serine racemase through cross-talk with the glutamatergic system and serotonin modulation. D-Cycloserine acts as a partial agonist at the NMDA receptor's glycine-binding site, indirectly affecting serine racemase by modulating NMDA receptor function. Nitric oxide, a signaling molecule, activates guanylate cyclase, leading to changes in cyclic guanosine monophosphate (cGMP) levels. The cGMP pathway alterations may indirectly impact serine racemase through intracellular signaling. Curcumin, with anti-inflammatory properties, modulates NF-kB signaling and inflammation-related processes, indirectly influencing serine racemase. Riluzole modulates glutamate release and inhibits excitotoxicity, indirectly affecting serine racemase through its connection to glutamatergic pathways.
7-Chlorokynurenic acid, a glycine site antagonist of the NMDA receptor, influences serine racemase by modulating glutamate signaling. Pentoxifylline, an anti-inflammatory agent, inhibits TNF-alpha production, indirectly impacting serine racemase through its effects on inflammatory pathways. AP5, a competitive NMDA receptor antagonist, directly blocks NMDA receptors, influencing serine racemase through the glutamatergic pathway. 4-Chlorokynurenine, a substrate for IDO, modulates glutamate levels through the kynurenine pathway, potentially affecting serine racemase. Valproic acid, an anticonvulsant, indirectly influences serine racemase through the interplay between GABAergic and glutamatergic systems. N-Acetylcysteine acts as a precursor to glutathione, impacting serine racemase by modulating oxidative stress-related signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Levodopa | 59-92-7 | sc-205372 sc-205372A | 5 g 25 g | $53.00 $168.00 | 9 | |
L-DOPA, or levodopa, is a precursor to dopamine and can indirectly influence serine racemase by modulating the dopaminergic system. Dopamine, through its downstream signaling, can impact various cellular pathways, potentially altering the activity of serine racemase. | ||||||
L-(-)-threo-3-Hydroxyaspartic acid | 7298-99-9 | sc-204033 | 10 mg | $214.00 | 1 | |
A compound known to inhibit serine racemase, potentially affecting the conversion of L-serine to D-serine. | ||||||
Fluoxetine | 54910-89-3 | sc-279166 | 500 mg | $312.00 | 9 | |
Fluoxetine, a selective serotonin reuptake inhibitor (SSRI), affects serotonin levels. Serotonin, in turn, can cross-talk with the glutamatergic system, influencing NMDA receptors. This interaction may indirectly impact serine racemase by modulating glutamatergic signaling pathways. | ||||||
Minocycline, Hydrochloride | 13614-98-7 | sc-203339 sc-203339A sc-203339B sc-203339C sc-203339D sc-203339E sc-203339F | 50 mg 250 mg 1 g 2.5 g 10 g 100 g 1 kg | $52.00 $168.00 $275.00 $622.00 $1234.00 $5722.00 $24490.00 | 36 | |
An antibiotic that has been found to inhibit serine racemase and potentially impact D-serine levels and NMDA receptor function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a natural polyphenol, exhibits anti-inflammatory properties and can modulate various signaling pathways. Its inhibitory effects on NF-kB signaling and inflammatory mediators may indirectly influence serine racemase through interactions with inflammation-related cellular processes. | ||||||
Riluzole | 1744-22-5 | sc-201081 sc-201081A sc-201081B sc-201081C | 20 mg 100 mg 1 g 25 g | $20.00 $189.00 $209.00 $311.00 | 1 | |
Riluzole modulates glutamate release and inhibits excitotoxicity. By affecting glutamatergic transmission, it can indirectly impact serine racemase, which is intricately connected to glutamatergic pathways. | ||||||
Pentoxifylline | 6493-05-6 | sc-203184 | 1 g | $20.00 | 3 | |
Pentoxifylline possesses anti-inflammatory properties and can inhibit TNF-alpha production. Through its modulation of inflammatory pathways, it may indirectly impact serine racemase, as inflammation is intricately linked to the regulation of various cellular processes, including glutamate signaling. | ||||||
D(−)-2-Amino-5-phosphonovaleric acid (D-AP5) | 79055-68-8 | sc-200434 | 5 mg | $95.00 | 2 | |
AP5 is a competitive NMDA receptor antagonist. By directly blocking the NMDA receptor, it can influence glutamate signaling, potentially affecting serine racemase through the modulation of the glutamatergic pathway. | ||||||
4-Chloro Kynurenine | 75802-84-5 | sc-505011 | 10 mg | $380.00 | ||
4-Chlorokynurenine is a substrate for indoleamine 2,3-dioxygenase (IDO), an enzyme involved in the metabolism of tryptophan. The kynurenine pathway, linked to IDO activity, can modulate glutamate levels and, consequently, may indirectly impact serine racemase through glutamatergic pathways. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid, an anticonvulsant, can influence GABAergic signaling. GABA, in turn, can cross-talk with glutamatergic pathways. The interplay between GABAergic and glutamatergic systems may indirectly affect serine racemase by modulating cellular processes related to glutamate regulation. | ||||||