Serglycin Antibody (C-11): sc-374657
- Serglycin Antibody (C-11) is a mouse monoclonal IgG2a κ Serglycin antibody, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 1-158 representing full length Serglycin of human origin
- Serglycin Antibody (C-11) is recommended for detection of precursor and mature Serglycin of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Serglycin Antibody (C-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Serglycin Antibody (C-11) for WB and IHC(P) applications. These reagents are now offered in bundles with Serglycin Antibody (C-11) (see ordering information below).
QUICK LINKS
SEE ALSO...
Serglycin Antibody (C-11) is a mouse monoclonal IgG2a kappa light chain antibody that detects Serglycin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Serglycin antibody (C-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. Serglycin, a chondroitin sulfate-bearing proteoglycan, plays a crucial role in the transport and storage of cationic granular proteins within secretory granules of hematopoietic cells. A protease-resistant peptide core characterizes Serglycin′s unique structure, essential for neutralizing hydrolytic enzymes and protecting granule contents. This structural feature allows Serglycin to associate with granzyme and perforin complexes, vital for granule-mediated apoptosis pathway utilized by cytotoxic T lymphocytes and natural killer cells. By facilitating granule exocytosis, Serglycin maintains normal immune function through elimination of virus-infected and tumor cells.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Serglycin Antibody (C-11) References:
- Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin. | Raja, SM., et al. 2002. J Biol Chem. 277: 49523-30. PMID: 12388539
- Serglycin proteoglycan expression and synthesis in embryonic stem cells. | Schick, BP., et al. 2003. Biochim Biophys Acta. 1593: 259-67. PMID: 12581870
- The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal. | Lieberman, J. 2003. Nat Rev Immunol. 3: 361-70. PMID: 12766758
- Targeting myeloperoxidase to azurophilic granules in HL-60 cells. | Lemansky, P., et al. 2003. J Leukoc Biol. 74: 542-50. PMID: 12960244
- The granzyme B-serglycin complex from cytotoxic granules requires dynamin for endocytosis. | Veugelers, K., et al. 2004. Blood. 103: 3845-53. PMID: 14739229
- Localization of serglycin in human neutrophil granulocytes and their precursors. | Niemann, CU., et al. 2004. J Leukoc Biol. 76: 406-15. PMID: 15136585
- Serglycin is essential for maturation of mast cell secretory granule. | Abrink, M., et al. 2004. J Biol Chem. 279: 40897-905. PMID: 15231821
- Serglycin proteoglycan deletion in mouse platelets: physiological effects and their implications for platelet contributions to thrombosis, inflammation, atherosclerosis, and metastasis. | Schick, BP. 2010. Prog Mol Biol Transl Sci. 93: 235-87. PMID: 20807648
- Serglycin is part of the secretory repertoire of LPS-activated monocytes. | Kolseth, IB., et al. 2015. Immun Inflamm Dis. 3: 23-31. PMID: 25866637
- Targeting Serglycin Prevents Metastasis in Murine Mammary Carcinoma. | Roy, A., et al. 2016. PLoS One. 11: e0156151. PMID: 27223472
- Association between Serum Serglycin Levels and St-Segment Elevation Myocardial Infarction. | Ilgın, BU., et al. 2021. Arq Bras Cardiol. 116: 756-762. PMID: 33886724
- Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration. | Chen, F., et al. 2024. Nat Commun. 15: 47. PMID: 38167807
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Serglycin Antibody (C-11) | sc-374657 | 200 µg/ml | $322.00 | |||
Serglycin Antibody (C-11): m-IgG Fc BP-HRP Bundle | sc-529792 | 200 µg Ab; 10 µg BP | $361.00 | |||
Serglycin Antibody (C-11): m-IgGκ BP-HRP Bundle | sc-522807 | 200 µg Ab, 40 µg BP | $361.00 | |||
Serglycin Antibody (C-11): m-IgG2a BP-HRP Bundle | sc-547380 | 200 µg Ab; 10 µg BP | $361.00 | |||
Serglycin Antibody (C-11) AC | sc-374657 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Serglycin Antibody (C-11) HRP | sc-374657 HRP | 200 µg/ml | $322.00 | |||
Serglycin Antibody (C-11) FITC | sc-374657 FITC | 200 µg/ml | $336.00 | |||
Serglycin Antibody (C-11) PE | sc-374657 PE | 200 µg/ml | $349.00 | |||
Serglycin Antibody (C-11) Alexa Fluor® 488 | sc-374657 AF488 | 200 µg/ml | $364.00 | |||
Serglycin Antibody (C-11) Alexa Fluor® 546 | sc-374657 AF546 | 200 µg/ml | $364.00 | |||
Serglycin Antibody (C-11) Alexa Fluor® 594 | sc-374657 AF594 | 200 µg/ml | $364.00 | |||
Serglycin Antibody (C-11) Alexa Fluor® 647 | sc-374657 AF647 | 200 µg/ml | $364.00 | |||
Serglycin Antibody (C-11) Alexa Fluor® 680 | sc-374657 AF680 | 200 µg/ml | $364.00 | |||
Serglycin Antibody (C-11) Alexa Fluor® 790 | sc-374657 AF790 | 200 µg/ml | $364.00 |