SERCA1 Antibody (6D138): sc-73019

SERCA1 Antibody (6D138) is a mouse monoclonal IgG1 antibody that detects SERCA1 in mouse, rat, human, rabbit, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). SERCA1, a member of the sarcoplasmic or endoplasmic reticulum calcium (SERCA) ATPase family, plays a crucial role in muscle physiology by mediating the uptake of calcium ions into the sarcoplasmic reticulum, which is essential for muscle contraction and relaxation. SERCA1 maintains low cytoplasmic calcium concentrations, preventing excessive muscle contraction and ensuring efficient muscle relaxation. SERCA1 is exclusively expressed in type II (fast) skeletal muscle, allowing for rapid and powerful muscle contractions. Dysregulation of SERCA1 can lead to impaired muscle function and has been implicated in various muscle-related diseases. Anti-SERCA1 antibody (6D138) serves as an invaluable tool for researchers studying calcium homeostasis and muscle physiology, providing insights into the molecular mechanisms underlying muscle contraction and relaxation.

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SERCA1 Antibody (6D138) References:

1. The mutation of Pro789 to Leu reduces the activity of the fast-twitch skeletal muscle sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA1) and is associated with Brody disease.  |  Odermatt, A., et al. 2000. Hum Genet. 106: 482-91. PMID: 10914677
2. The nature of the low-frequency normal modes of the E1Ca form of the SERCA1 Ca2+-ATPase.  |  Reuter, N., et al. 2003. Ann N Y Acad Sci. 986: 344-6. PMID: 12763846
3. Transconformations of the SERCA1 Ca-ATPase: a normal mode study.  |  Reuter, N., et al. 2003. Biophys J. 85: 2186-97. PMID: 14507684
4. Measurement of Ca2+-ATPase activity (in PMCA and SERCA1).  |  Kosk-Kosicka, D. 2006. Methods Mol Biol. 312: 343-54. PMID: 16422209
5. Intermolecular interactions in the mechanism of skeletal muscle sarcoplasmic reticulum Ca(2+)-ATPase (SERCA1): evidence for a triprotomer.  |  Mahaney, JE., et al. 2008. Biochemistry. 47: 13711-25. PMID: 19046074
6. Brody disease: insights into biochemical features of SERCA1 and identification of a novel mutation.  |  Vattemi, G., et al. 2010. J Neuropathol Exp Neurol. 69: 246-52. PMID: 20142766
7. SERCA-1 conformational change exerted by the Ca2+-channel blocker diltiazem affects mammalian skeletal muscle function.  |  Jiménez-Garduño, A., et al. 2024. Cell Calcium. 119: 102852. PMID: 38412581
8. Identification of new small molecules for selective inhibition of SERCA 1 in patient-derived metastatic papillary thyroid cancer.  |  Kim, SM., et al. 2025. Br J Pharmacol.. PMID: 39924143
9. Characterization of cDNA and genomic DNA encoding SERCA1, the Ca(2+)-ATPase of human fast-twitch skeletal muscle sarcoplasmic reticulum, and its elimination as a candidate gene for Brody disease.  |  Zhang, Y., et al. 1995. Genomics. 30: 415-24. PMID: 8825625
10. Correlations between MyoD, myogenin, SERCA1, SERCA2 and phospholamban transcripts during transformation of type-II to type-I skeletal muscle fibers.  |  Hu, P., et al. 1997. Pflugers Arch. 434: 209-11. PMID: 9136677

The preferred SERCA1/2/3 antibody is SERCA1/2/3 Antibody (B-7): sc-271669.