Septin 8 Antibody (D-7): sc-390105

Septin 8 Antibody (D-7) is a mouse monoclonal IgG2a antibody that detects Septin 8 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Septin 8 is a 508 amino acid protein that plays a crucial role in the organization of the cytoskeleton and is primarily located in the cytoplasm, where Septin 8 contributes to the formation of higher-order filamentous structures essential for cellular integrity and function. The localization of Septin 8 is particularly important as Septin 8 is involved in various cellular processes such as vesicle trafficking, apoptosis, and cytokinesis, which are vital for maintaining normal cellular activities and responses to stress. Additionally, Septin 8 interacts with other septins, including Septin 5 and cell division cycle related-1 (CDCrel-1), highlighting Septin 8′s role in complex protein networks that regulate cell division and signaling pathways. The ability of Septin 8 to form oligomeric structures allows Septin 8 to act as a dynamic scaffold, facilitating the assembly of other proteins and contributing to the overall architecture of the cytoskeleton. This makes Septin 8 not only a key player in cellular organization but also a potential target for studying diseases related to cytoskeletal dysfunction, such as neurodegeneration and cancer.

The preferred Septin 8 antibody is Septin 8 Antibody (C-5): sc-390074.