Septin 1 Antibody (H-10): sc-373925

Septin 1 Antibody (H-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects Septin 1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Septin 1 antibody (H-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Septin 1 is a member of the septin family of GTPase enzymes, which are crucial for various cellular processes, including cytokinesis and exocytosis. Septin 1′s ability to form heteropolymer complexes is vital for maintaining cellular organization and facilitating new growth in organisms. Notably, Septin 1 interacts with other septins, such as Septin 2 and Septin 4, which are implicated in the formation of neurofibrillary tangles associated with neurodegenerative diseases. The complex transcriptional regulation of septins leads to the generation of alternatively spliced variants, further diversifying their functional roles. Septin 1′s involvement in the assembly of septin filaments highlights its importance in cellular architecture and signaling pathways, making it a significant target for research in cell biology and neurobiology.

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Septin 1 Antibody (H-10) References:

1. Phosphorylation of a new brain-specific septin, G-septin, by cGMP-dependent protein kinase.  |  Xue, J., et al. 2000. J Biol Chem. 275: 10047-56. PMID: 10744683
2. Reciprocal expression of infant- and adult-preferring transcripts of CDCrel-1 septin gene in the rat neocortex.  |  Toda, S., et al. 2000. Biochem Biophys Res Commun. 273: 723-8. PMID: 10873671
3. Alternative exon usage of rat septins.  |  Jackisch, BO., et al. 2000. Biochem Biophys Res Commun. 275: 180-8. PMID: 10944462
4. A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif.  |  Larisch, S., et al. 2000. Nat Cell Biol. 2: 915-21. PMID: 11146656
5. Characterization of the Aspergillus nidulans septin (asp) gene family.  |  Momany, M., et al. 2001. Genetics. 157: 969-77. PMID: 11238387
6. An ins(X;11)(q24;q23) fuses the MLL and the Septin 6/KIAA0128 gene in an infant with AML-M2.  |  Borkhardt, A., et al. 2001. Genes Chromosomes Cancer. 32: 82-8. PMID: 11477664
7. Identification of septins in neurofibrillary tangles in Alzheimer's disease.  |  Kinoshita, A., et al. 1998. Am J Pathol. 153: 1551-60. PMID: 9811347

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Septin 1 Antibody (H-10) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Septin 1 Antibody (H-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Septin 1 Antibody (H-10) Specifications

Alternate Product Name: Septin 1

Product Clone Name: H-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 224-251

Epitope Target: Septin 1

Epitope Species: human

Product Reactivity/Detection: Septin 1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Septin 1 Antibody (H-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred Septin 1 antibody is Septin 1 Antibody (B-8): sc-398586.