SENP8 Antibody (E-11): sc-271498

SENP8 Antibody (E-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects SENP8 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). anti-SENP8 antibody (E-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SENP8 plays a crucial role in regulating the SUMO (small ubiquitin-related modifier) pathway, which is essential for various cellular processes such as transcription, DNA repair, and cell cycle regulation. Specifically, SENP8 is involved in the desumoylation of target proteins, a process vital for maintaining cellular homeostasis and responding to stress signals. SENP8′s ability to modulate the sumoylation status of proteins can influence stability, localization, and activity, thereby impacting critical biological functions. SENP8 also interacts with other sentrin-specific proteases, contributing to the dynamic regulation of SUMO modifications. Understanding SENP8′s function and interactions is important for elucidating mechanisms underlying cellular responses to environmental changes and disease states.

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SENP8 Antibody (E-11) References:

1. Differential regulation of sentrinized proteins by a novel sentrin-specific protease.  |  Gong, L., et al. 2000. J Biol Chem. 275: 3355-9. PMID: 10652325
2. A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs.  |  Kim, KI., et al. 2000. J Biol Chem. 275: 14102-6. PMID: 10799485
3. SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1.  |  Cheng, J., et al. 2004. Mol Cell Biol. 24: 6021-8. PMID: 15199155
4. A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex.  |  Reverter, D. and Lima, CD. 2004. Structure. 12: 1519-31. PMID: 15296745
5. Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1.  |  Xu, Z. and Au, SW. 2005. Biochem J. 386: 325-30. PMID: 15487983
6. Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1.  |  Kim, YH., et al. 2005. FEBS Lett. 579: 6272-8. PMID: 16253240
7. The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing.  |  Shen, LN., et al. 2006. Biochem J. 397: 279-88. PMID: 16553580
8. Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3.  |  Gong, L. and Yeh, ET. 2006. J Biol Chem. 281: 15869-77. PMID: 16608850
9. The SUMO-specific protease SENP5 is required for cell division.  |  Di Bacco, A., et al. 2006. Mol Cell Biol. 26: 4489-98. PMID: 16738315
10. Neddylation of PTEN regulates its nuclear import and promotes tumor development.  |  Xie, P., et al. 2021. Cell Res. 31: 291-311. PMID: 33299139
11. SHP2 deneddylation mediates tumor immunosuppression in colon cancer via the CD47/SIRPα axis.  |  Li, Y., et al. 2023. J Clin Invest. 133: PMID: 36626230
12. Deneddylating enzyme SENP8 regulates neuronal development.  |  Song, JM., et al. 2023. J Neurochem. 165: 348-361. PMID: 36847487

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SENP8 Antibody (E-11) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-SENP8 Antibody (E-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SENP8 Antibody (E-11) Specifications

Alternate Product Name: SENP8

Product Clone Name: E-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-212

Epitope Target: SENP8

Epitope Species: human

Product Reactivity/Detection: SENP8

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for SENP8 Antibody (E-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin