SENP6 Antibody (79-M): sc-100585

SENP6 Antibody (79-M) is a mouse monoclonal IgG2a kappa light chain antibody that detects SENP6 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). SENP6 (79-M) antibody is available as the non-conjugated anti-SENP6 monoclonal isotype antibody. SENP6 plays a crucial role in regulating SUMO (small ubiquitin-related modifier) pathways, which are essential for various cellular functions, including transcriptional regulation, DNA repair, and cellular signaling. SENP6 localizes in the cytoplasm and participates in releasing SUMO-1 from conjugated forms, thereby influencing sumoylation and desumoylation processes. This activity affects the stability and function of target proteins, including those involved in reproductive processes, as SENP6 expression shows higher levels in reproductive organs. Through modulation of SUMO-conjugated protein levels, SENP6 impacts critical cellular functions and pathways, making SENP6 significant in cellular homeostasis and reproductive biology.

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SENP6 Antibody (79-M) References:

1. Differential regulation of sentrinized proteins by a novel sentrin-specific protease.  |  Gong, L., et al. 2000. J Biol Chem. 275: 3355-9. PMID: 10652325
2. A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs.  |  Kim, KI., et al. 2000. J Biol Chem. 275: 14102-6. PMID: 10799485
3. SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1.  |  Cheng, J., et al. 2004. Mol Cell Biol. 24: 6021-8. PMID: 15199155
4. A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex.  |  Reverter, D. and Lima, CD. 2004. Structure. 12: 1519-31. PMID: 15296745
5. Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1.  |  Xu, Z. and Au, SW. 2005. Biochem J. 386: 325-30. PMID: 15487983
6. Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1.  |  Kim, YH., et al. 2005. FEBS Lett. 579: 6272-8. PMID: 16253240
7. The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing.  |  Shen, LN., et al. 2006. Biochem J. 397: 279-88. PMID: 16553580
8. Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3.  |  Gong, L. and Yeh, ET. 2006. J Biol Chem. 281: 15869-77. PMID: 16608850
9. The SUMO-specific protease SENP5 is required for cell division.  |  Di Bacco, A., et al. 2006. Mol Cell Biol. 26: 4489-98. PMID: 16738315

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SENP6 Antibody (79-M) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-SENP6 Antibody (79-M) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SENP6 Antibody (79-M) Specifications

Alternate Product Name: SENP6

Product Clone Name: 79-M

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-111

Epitope Target: SENP6

Epitope Species: human

Product Reactivity/Detection: SENP6

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for SENP6 Antibody (79-M): N/A