SENP1 Antibody (C-12): sc-271360

SENP1 Antibody (C-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects SENP1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SENP1 (C-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SENP1 protein plays a crucial role in regulating the small ubiquitin-related modifier (SUMO) pathway, which is essential for various cellular processes such as transcription, DNA repair, and cellular localization. SENP1 specifically functions as a SUMO-specific protease that removes SUMO modifications from target proteins, thereby influencing their activity and stability. This post-translational modification is vital because it can alter protein interactions and localization, impacting critical cellular functions. For instance, SENP1 desumoylates HIPK2, a protein involved in stress response and apoptosis, facilitating its nuclear export and subsequent degradation. The ability of SENP1 to modulate the sumoylation status of proteins underscores its importance in maintaining cellular homeostasis and responding to environmental cues. With versatile applications and significant role in cellular regulation, anti-SENP1 antibody (C-12) serves as an invaluable tool for researchers studying the SUMO pathway and its implications in various biological processes.

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SENP1 Antibody (C-12) References:

1. Differential regulation of sentrinized proteins by a novel sentrin-specific protease.  |  Gong, L., et al. 2000. J Biol Chem. 275: 3355-9. PMID: 10652325
2. A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs.  |  Kim, KI., et al. 2000. J Biol Chem. 275: 14102-6. PMID: 10799485
3. SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1.  |  Cheng, J., et al. 2004. Mol Cell Biol. 24: 6021-8. PMID: 15199155
4. A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex.  |  Reverter, D. and Lima, CD. 2004. Structure. 12: 1519-31. PMID: 15296745
5. Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1.  |  Xu, Z. and Au, SW. 2005. Biochem J. 386: 325-30. PMID: 15487983
6. Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1.  |  Kim, YH., et al. 2005. FEBS Lett. 579: 6272-8. PMID: 16253240
7. The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing.  |  Shen, LN., et al. 2006. Biochem J. 397: 279-88. PMID: 16553580
8. Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3.  |  Gong, L. and Yeh, ET. 2006. J Biol Chem. 281: 15869-77. PMID: 16608850
9. The SUMO-specific protease SENP5 is required for cell division.  |  Di Bacco, A., et al. 2006. Mol Cell Biol. 26: 4489-98. PMID: 16738315

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SENP1 Antibody (C-12) has 22 citations in a variety of scientific publications.

Primary antibodies like Anti-SENP1 Antibody (C-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SENP1 Antibody (C-12) Specifications

Alternate Product Name: SENP1

Product Clone Name: C-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 361-425

Epitope Target: SENP1

Epitope Species: human

Product Reactivity/Detection: SENP1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 22 citations in various scientific publications

Available Conjugates/Forms for SENP1 Antibody (C-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin