SEN15 Antibody (D-3): sc-374085

SEN15 Antibody (D-3) is a mouse monoclonal IgG2a antibody that detects SEN15 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SEN15, also known as TSEN15 or C1orf19, is a crucial nuclear protein involved in the splicing of tRNA, a process essential for the proper maturation of tRNA molecules. SEN15 is predominantly expressed in the testis and uterus, highlighting its potential role in reproductive biology. As a non-catalytic subunit of the multi-protein tRNA-splicing endonuclease complex, SEN15 is integral to the identification and cleavage of pre-tRNA at both the 5′ and 3′ splice sites, which is vital for the removal of introns and the generation of functional tRNA molecules. Furthermore, SEN15′s involvement in mRNA processing, through interactions with pre-mRNA processing factors, suggests a significant role in coordinating the splicing of both tRNA and mRNA, thereby influencing protein expression and cellular growth and division. Anti-SEN15 antibody (D-3) is an invaluable tool for researchers studying the intricacies of RNA processing and its implications in various biological processes.

The preferred SEN15 antibody is SEN15 Antibody (F-4): sc-374083.