Sec8 Antibody (14): sc-136234
- Sec8 Antibody (14) is a mouse monoclonal IgG2b, cited in 5 publications, provided at 50 µg/0.5 ml
- raised against amino acids 31-201 of Sec8 of rat origin
- recommended for detection of Sec8 of mouse, rat, human and canine origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Sec8 Antibody (14). This work is in progress.
Sec8 Antibody (14) is a mouse monoclonal IgG2b antibody that detects Sec8 in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Sec8, also known as EXOC4, REC8, or SEC8L1, is a critical component of the exocyst complex, which plays a vital role in exocytosis, a process essential for membrane trafficking, hormone and neurotransmitter secretion, and the incorporation of membrane proteins and lipids into the plasma membrane. The exocyst complex, composed of eight protein subunits including Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70, and Exo84, is crucial for targeting exocytic vesicles to specific docking sites on the plasma membrane, thereby facilitating effective cell-cell communication, cell growth, and maintaining cell polarity. Notably, Sec8′s interaction with other proteins in the exocyst complex is essential for modulating microtubule dynamics, which are fundamental to the exocytosis process. The human Sec8 gene is located on chromosome 7q33, and proper function is vital for maintaining cellular homeostasis and signaling pathways. anti-Sec8 antibody (14) is an invaluable tool for researchers studying the mechanisms of exocytosis and its implications in various physiological and pathological processes.
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Sec8 Antibody (14) References:
- The mammalian Sec6/8 complex interacts with Ca(2+) signaling complexes and regulates their activity. | Shin, DM., et al. 2000. J Cell Biol. 150: 1101-12. PMID: 10973998
- Increased synaptic microtubules and altered synapse development in Drosophila sec8 mutants. | Liebl, FL., et al. 2005. BMC Biol. 3: 27. PMID: 16351720
- Insulin stimulates the phosphorylation of the exocyst protein Sec8 in adipocytes. | Lyons, PD., et al. 2009. Biosci Rep. 29: 229-35. PMID: 19006485
- Arabidopsis exocyst subunits SEC8 and EXO70A1 and exocyst interactor ROH1 are involved in the localized deposition of seed coat pectin. | Kulich, I., et al. 2010. New Phytol. 188: 615-25. PMID: 20618910
- Exocyst complex component Sec8: a presumed component in the progression of human oral squamous-cell carcinoma by secretion of matrix metalloproteinases. | Yamamoto, A., et al. 2013. J Cancer Res Clin Oncol. 139: 533-42. PMID: 23207790
- Sec6/8 regulates Bcl-2 and Mcl-1, but not Bcl-xl, in malignant peripheral nerve sheath tumor cells. | Tanaka, T., et al. 2016. Apoptosis. 21: 594-608. PMID: 26892009
- Diverse Functions and Signal Transduction of the Exocyst Complex in Tumor Cells. | Tanaka, T., et al. 2017. J Cell Physiol. 232: 939-957. PMID: 27669116
- The exocyst is required for melanin exocytosis from melanocytes and transfer to keratinocytes. | Moreiras, H., et al. 2020. Pigment Cell Melanoma Res. 33: 366-371. PMID: 31665827
- Septin-mediated RhoA activation engages the exocyst complex to recruit the cilium transition zone. | Safavian, D., et al. 2023. J Cell Biol. 222: PMID: 36912772
- The secretory protein Sec8 is required for paraxial mesoderm formation in the mouse. | Friedrich, GA., et al. 1997. Dev Biol. 192: 364-74. PMID: 9441674
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sec8 Antibody (14) | sc-136234 | 50 µg/0.5 ml | $316.00 |