SEC22B Antibody (29-F7): sc-101267

SEC22B Antibody (29-F7) is a mouse monoclonal IgG2a antibody that detects SEC22B protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-SEC22B antibody (29-F7) is available as a non-conjugated format. SEC22B protein, also known as SEC22L1 or ERS-24, is a crucial component of the vesicular transport system, functioning as a v-SNARE that facilitates protein transport between the endoplasmic reticulum (ER) and the Golgi apparatus. SEC22B is essential for maintaining cellular homeostasis and ensuring proper protein sorting and delivery, which is vital for various cellular processes, including secretion and membrane trafficking. SEC22B is a single-pass type IV membrane protein that belongs to the synaptobrevin family and features a v-SNARE coiled-coil homology domain and a longin domain. SEC22B is primarily localized to the ER-Golgi intermediate compartment and is found on ER-derived vesicles, where SEC22B plays a pivotal role in ER-Golgi transport. SEC22B interaction with cognate t-SNARE proteins, such as Syntaxin 5, Bet1, and GS27, as well as participation in SNARE complexes with Syntaxin 18, Nip1, and USE1 (p31), underscores SEC22B importance in the vesicular transport mechanism. Using SEC22B (29-F7) antibody in your research can provide valuable insights into the dynamics of intracellular transport and the functional implications of SEC22B in various biological contexts.

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SEC22B Antibody (29-F7) References:

1. Legionella subvert the functions of Rab1 and Sec22b to create a replicative organelle.  |  Kagan, JC., et al. 2004. J Exp Med. 199: 1201-11. PMID: 15117975
2. Differential use of endoplasmic reticulum membrane for phagocytosis in J774 macrophages.  |  Becker, T., et al. 2005. Proc Natl Acad Sci U S A. 102: 4022-6. PMID: 15753287
3. Evidence for regulation of ER/Golgi SNARE complex formation by hsc70 chaperones.  |  Joglekar, AP. and Hay, JC. 2005. Eur J Cell Biol. 84: 529-42. PMID: 16003907
4. Immuno-electron tomography of ER exit sites reveals the existence of free COPII-coated transport carriers.  |  Zeuschner, D., et al. 2006. Nat Cell Biol. 8: 377-83. PMID: 16531996
5. Involvement of syntaxin 18, an endoplasmic reticulum (ER)-localized SNARE protein, in ER-mediated phagocytosis.  |  Hatsuzawa, K., et al. 2006. Mol Biol Cell. 17: 3964-77. PMID: 16790498
6. Identification of the yeast R-SNARE Nyv1p as a novel longin domain-containing protein.  |  Wen, W., et al. 2006. Mol Biol Cell. 17: 4282-99. PMID: 16855025
7. Sec22b-dependent assembly of endoplasmic reticulum Q-SNARE proteins.  |  Aoki, T., et al. 2008. Biochem J. 410: 93-100. PMID: 17979832
8. The identification of the SNARE complex required for the fusion of VLDL-transport vesicle with hepatic cis-Golgi.  |  Siddiqi, S., et al. 2010. Biochem J. 429: 391-401. PMID: 20450495
9. Extended-synaptotagmin 1 engages in unconventional protein secretion mediated via SEC22B+ vesicle pathway in liver cancer.  |  Yamada, K., et al. 2022. Proc Natl Acad Sci U S A. 119: e2202730119. PMID: 36044553
10. Sec22b is a critical and nonredundant regulator of plasma cell maintenance.  |  Bonaud, A., et al. 2023. Proc Natl Acad Sci U S A. 120: e2213056120. PMID: 36595686
11. It takes a sec(22b) to accrue plasma cells.  |  Mulder, J., et al. 2023. Immunol Cell Biol. 101: 285-288. PMID: 36789450
12. Morphological and functional association of Sec22b/ERS-24 with the pre-Golgi intermediate compartment.  |  Zhang, T., et al. 1999. Mol Biol Cell. 10: 435-53. PMID: 9950687

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SEC22B Antibody (29-F7) has 22 citations in a variety of scientific publications.

Primary antibodies like Anti-SEC22B Antibody (29-F7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SEC22B Antibody (29-F7) Specifications

Alternate Product Name: SEC22B

Product Clone Name: 29-F7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a lambda light chain

Amino Acids: 1-110

Epitope Target: SEC22B

Epitope Species: human

Product Reactivity/Detection: SEC22B

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a lambda light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 22 citations in various scientific publications

Available Conjugates/Forms for SEC22B Antibody (29-F7): N/A