SEC14L2 Antibody (H-4): sc-271905

SEC14L2 Antibody (H-4) is a mouse monoclonal IgM antibody that detects SEC14L2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-SEC14L2 antibody (H-4) is available as a non-conjugated monoclonal isotype antibody. SEC14L2, also known as supernatant protein factor (SPF), α-tocopherol-associated protein, or squalene transfer protein, plays a crucial role in lipid metabolism by functioning as a carrier protein that transfers tocopherols and acts as a transcriptional activator through interaction with α-tocopherol. This interaction maintains cellular health and regulates gene expression related to antioxidant defense. SEC14L2 is predominantly expressed in liver, brain, intestine, and prostate, highlighting importance in various physiological processes. While SEC14L2 is primarily localized in cytoplasm, nuclear presence is induced by α-tocopherol, suggesting a regulatory mechanism that may influence gene transcription. SEC14L2 activity is modulated by post-translational modifications, particularly phosphorylation by protein kinase A and protein kinase C, which are essential for functional regulation and interaction with other cellular pathways.

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SEC14L2 Antibody (H-4) References:

1. Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis.  |  Shibata, N., et al. 2001. Proc Natl Acad Sci U S A. 98: 2244-9. PMID: 11226224
2. Phosphorylation of supernatant protein factor enhances its ability to stimulate microsomal squalene monooxygenase.  |  Singh, DK., et al. 2003. J Biol Chem. 278: 5646-51. PMID: 12454003
3. Supernatant protein factor in complex with RRR-alpha-tocopherylquinone: a link between oxidized Vitamin E and cholesterol biosynthesis.  |  Stocker, A. and Baumann, U. 2003. J Mol Biol. 332: 759-65. PMID: 12972248
4. Supernatant protein factor stimulates HMG-CoA reductase in cell culture and in vitro.  |  Mokashi, V., et al. 2005. Arch Biochem Biophys. 433: 474-80. PMID: 15581604
5. Regulation of hepatic cholesterol synthesis by a novel protein (SPF) that accelerates cholesterol biosynthesis.  |  Shibata, N., et al. 2006. FASEB J. 20: 2642-4. PMID: 17077281
6. Effects of a supernatant protein activator on microsomal squalene-2,3-oxide-lanosterol cyclase.  |  Caras, IW. and Bloch, K. 1979. J Biol Chem. 254: 11816-21. PMID: 500676
7. Role of supernatant protein factor and anionic phospholipid in squalene uptake and conversion by microsomes.  |  Chin, J. and Bloch, K. 1984. J Biol Chem. 259: 11735-8. PMID: 6480582
8. Supernatant protein factor facilitates intermembrane transfer of squalene.  |  Friedlander, EJ., et al. 1980. J Biol Chem. 255: 8042-5. PMID: 7410347

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SEC14L2 Antibody (H-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-SEC14L2 Antibody (H-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SEC14L2 Antibody (H-4) Specifications

Alternate Product Name: SEC14L2

Product Clone Name: H-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 1-300

Epitope Target: SEC14L2

Epitope Species: human

Product Reactivity/Detection: SEC14L2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for SEC14L2 Antibody (H-4): N/A

The preferred SEC14L2/L3/L4 antibody is SEC14L2/L3/L4 Antibody (E-10): sc-365420.