SEC13 Antibody (F-6): sc-514308

SEC13 Antibody (F-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects SEC13 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SEC13 (F-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SEC13 plays a crucial role in forming transport vesicles within the secretory pathway, particularly in the context of the endoplasmic reticulum (ER). SEC13 functions as a key component of the COPII vesicle coat complex, which is essential for transporting secretory proteins from the ER to the Golgi apparatus. SEC13 forms a hetero-octameric complex with SEC31, vital for the stability and functionality of the COPII coat, ensuring efficient vesicle budding and cargo selection. Understanding SEC13 structural dynamics and interactions with other proteins in the COPII complex helps explain intracellular transport and secretory pathway mechanisms, which maintain cellular homeostasis and function.

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SEC13 Antibody (F-6) References:

1. Sec13 shuttles between the nucleus and the cytoplasm and stably interacts with Nup96 at the nuclear pore complex.  |  Enninga, J., et al. 2003. Mol Cell Biol. 23: 7271-84. PMID: 14517296
2. Sec13 Regulates Expression of Specific Immune Factors Involved in Inflammation In Vivo.  |  Moreira, TG., et al. 2015. Sci Rep. 5: 17655. PMID: 26631972
3. Sec13 is a positive regulator of VISA-mediated antiviral signaling.  |  Chen, T., et al. 2018. Virus Genes. 54: 514-526. PMID: 29948782
4. Sec13 promotes oligodendrocyte differentiation and myelin repair through autocrine pleiotrophin signaling.  |  Liu, Z., et al. 2022. J Clin Invest. 132: PMID: 35143418
5. SPOP negatively regulates mTORC1 activity by ubiquitinating Sec13.  |  Yang, Y., et al. 2024. Cell Signal. 116: 111060. PMID: 38242269
6. COPII cage assembly factor Sec13 integrates information flow regulating endomembrane function in response to human variation.  |  Anglès, F., et al. 2024. Sci Rep. 14: 10160. PMID: 38698045
7. Sec13 promotes glycolysis by inhibiting Ubqln1 mediated Pgm1 ubiquitination in ALI.  |  Wu, D., et al. 2024. Biochim Biophys Acta Mol Basis Dis. 1870: 167475. PMID: 39159700
8. Transcriptional studies on yeast SEC genes provide no evidence for regulation at the transcriptional level.  |  Vahlensieck, Y., et al. 1995. Yeast. 11: 901-11. PMID: 8533466
9. Sec31 encodes an essential component of the COPII coat required for transport vesicle budding from the endoplasmic reticulum.  |  Salama, NR., et al. 1997. Mol Biol Cell. 8: 205-17. PMID: 9190202
10. COPII subunit interactions in the assembly of the vesicle coat.  |  Shaywitz, DA., et al. 1997. J Biol Chem. 272: 25413-6. PMID: 9325247
11. Protein and lipid sorting between the endoplasmic reticulum and the Golgi complex.  |  Nickel, W., et al. 1998. Semin Cell Dev Biol. 9: 493-501. PMID: 9835636
12. Identification of SEC12, SED4, truncated SEC16, and EKS1/HRD3 as multicopy suppressors of ts mutants of Sar1 GTPase.  |  Saito, Y., et al. 1999. J Biochem. 125: 130-7. PMID: 9880808

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SEC13 Antibody (F-6) has 15 citations in a variety of scientific publications.

Primary antibodies like Anti-SEC13 Antibody (F-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SEC13 Antibody (F-6) Specifications

Alternate Product Name: SEC13

Product Clone Name: F-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 81-322

Epitope Target: SEC13

Epitope Species: human

Product Reactivity/Detection: SEC13

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 15 citations in various scientific publications

Available Conjugates/Forms for SEC13 Antibody (F-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin