Sec10 Antibody (C-4): sc-514802
- Sec10 Antibody (C-4) is a mouse monoclonal IgG2a κ Sec10 antibody, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of Sec10 of human origin
- Sec10 Antibody (C-4) is recommended for detection of Sec10 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Sec10 Antibody (C-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Sec10 Antibody (C-4) for WB applications. These reagents are now offered in bundles with Sec10 Antibody (C-4) (see ordering information below).
Sec10 Antibody (C-4) is a mouse monoclonal IgG2a kappa light chain antibody that detects Sec10 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Sec10 (C-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Sec10 protein plays a crucial role in the mammalian exocyst complex, which is essential for the targeting of exocytic vesicles to specific docking sites on the plasma membrane, thereby facilitating the secretion of proteins and other molecules. This process is vital for numerous cellular functions, including cell signaling, growth, and tissue repair. Sec10 is one of eight protein subunits that make up the exocyst complex, which also includes Sec3, Sec5, Sec6, Sec8, Sec15, Exo70, and Exo84. Notably, Sec10, also referred to as the 71 kDa component of the rsec6/8 secretory complex in mouse and rat, has a molecular weight of 77 kDa and forms a subcomplex with Sec15. In humans, the Sec10 gene is located on chromosome 14q22.3, highlighting its evolutionary conservation and importance across species.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Sec10 Antibody (C-4) References:
- Exocyst is involved in cystogenesis and tubulogenesis and acts by modulating synthesis and delivery of basolateral plasma membrane and secretory proteins. | Lipschutz, JH., et al. 2000. Mol Biol Cell. 11: 4259-75. PMID: 11102522
- The multiprotein exocyst complex is essential for cell separation in Schizosaccharomyces pombe. | Wang, H., et al. 2002. Mol Biol Cell. 13: 515-29. PMID: 11854409
- The exocyst affects protein synthesis by acting on the translocation machinery of the endoplasmic reticulum. | Lipschutz, JH., et al. 2003. J Biol Chem. 278: 20954-60. PMID: 12665531
- ARF6 controls post-endocytic recycling through its downstream exocyst complex effector. | Prigent, M., et al. 2003. J Cell Biol. 163: 1111-21. PMID: 14662749
- The exocyst complex in polarized exocytosis. | Hsu, SC., et al. 2004. Int Rev Cytol. 233: 243-65. PMID: 15037366
- Identification and characterization of homologues of the Exocyst component Sec10p. | Guo, W., et al. 1997. FEBS Lett. 404: 135-9. PMID: 9119050
- Dominant negative alleles of SEC10 reveal distinct domains involved in secretion and morphogenesis in yeast. | Roth, D., et al. 1998. Mol Biol Cell. 9: 1725-39. PMID: 9658167
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sec10 Antibody (C-4) | sc-514802 | 200 µg/ml | $316.00 | |||
Sec10 Antibody (C-4): m-IgG Fc BP-HRP Bundle | sc-526391 | 200 µg Ab; 10 µg BP | $354.00 | |||
Sec10 Antibody (C-4): m-IgG2a BP-HRP Bundle | sc-546619 | 200 µg Ab; 10 µg BP | $354.00 | |||
Sec10 Antibody (C-4) AC | sc-514802 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Sec10 Antibody (C-4) HRP | sc-514802 HRP | 200 µg/ml | $316.00 | |||
Sec10 Antibody (C-4) FITC | sc-514802 FITC | 200 µg/ml | $330.00 | |||
Sec10 Antibody (C-4) PE | sc-514802 PE | 200 µg/ml | $343.00 | |||
Sec10 Antibody (C-4) Alexa Fluor® 488 | sc-514802 AF488 | 200 µg/ml | $357.00 | |||
Sec10 Antibody (C-4) Alexa Fluor® 546 | sc-514802 AF546 | 200 µg/ml | $357.00 | |||
Sec10 Antibody (C-4) Alexa Fluor® 594 | sc-514802 AF594 | 200 µg/ml | $357.00 | |||
Sec10 Antibody (C-4) Alexa Fluor® 647 | sc-514802 AF647 | 200 µg/ml | $357.00 | |||
Sec10 Antibody (C-4) Alexa Fluor® 680 | sc-514802 AF680 | 200 µg/ml | $357.00 | |||
Sec10 Antibody (C-4) Alexa Fluor® 790 | sc-514802 AF790 | 200 µg/ml | $357.00 |