SDHA Antibody (C-8): sc-377302
- SDHA Antibody (C-8) is a mouse monoclonal IgG2b κ, cited in 5 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 637-664 at the C-terminus of SDHA of human origin
- recommended for detection of precursor and mature SDHA of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including porcine
- m-IgGκ BP-HRP is the preferred secondary detection reagent for SDHA Antibody (C-8) for WB applications. This reagent is now offered in a bundle with SDHA Antibody (C-8) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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SDHA Antibody (C-8) is a mouse monoclonal IgG2b antibody that detects succinate dehydrogenase A (SDHA) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SDHA plays a crucial role in the mitochondrial respiratory chain, specifically in the conversion of succinate to fumarate, which is essential for aerobic respiration and energy production in cells. Mutations in SDHA can lead to severe mitochondrial dysfunction and are linked to various genetic disorders, including juvenile encephalopathy and Leigh Syndrome. SDHA is located within the inner mitochondrial membrane, where SDHA forms part of a larger enzyme complex that includes SDHB, SDHC, and SDHD subunits. This localization enables SDHA to effectively participate in the electron transport chain, facilitating electron transfer and contributing to ATP synthesis. Anti-SDHA antibody (C-8) serves as an invaluable tool for researchers studying mitochondrial function and SDHA mutations in human health and disease.
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SDHA Antibody (C-8) References:
- Loss of SDHA expression identifies SDHA mutations in succinate dehydrogenase-deficient gastrointestinal stromal tumors. | Dwight, T., et al. 2013. Am J Surg Pathol. 37: 226-33. PMID: 23060355
- Familial SDHA mutation associated with pituitary adenoma and pheochromocytoma/paraganglioma. | Dwight, T., et al. 2013. J Clin Endocrinol Metab. 98: E1103-8. PMID: 23633203
- SDHB/SDHA immunohistochemistry in pheochromocytomas and paragangliomas: a multicenter interobserver variation analysis using virtual microscopy: a Multinational Study of the European Network for the Study of Adrenal Tumors (ENS@T). | Papathomas, TG., et al. 2015. Mod Pathol. 28: 807-21. PMID: 25720320
- First-positive surveillance screening in an asymptomatic SDHA germline mutation carrier. | White, G., et al. 2019. Endocrinol Diabetes Metab Case Rep. 2019: PMID: 31368675
- Elevated Endogenous SDHA Drives Pathological Metabolism in Highly Metastatic Uveal Melanoma. | Chattopadhyay, C., et al. 2019. Invest Ophthalmol Vis Sci. 60: 4187-4195. PMID: 31596927
- MicroRNA-16-5p exacerbates sepsis by upregulating aerobic glycolysis via SIRT3-SDHA axis. | He, YX., et al. 2022. Cell Biol Int. 46: 2207-2219. PMID: 36153644
- PIKE-A Modulates Mitochondrial Metabolism through Increasing SDHA Expression Mediated by STAT3/FTO Axis. | Sun, M., et al. 2022. Int J Mol Sci. 23: PMID: 36232604
- Upregulation of Succinate Dehydrogenase (SDHA) Contributes to Enhanced Bioenergetics of Ovarian Cancer Cells and Higher Sensitivity to Anti-Metabolic Agent Shikonin. | Wang, L., et al. 2022. Cancers (Basel). 14: PMID: 36291881
- Measuring Tumor Succinate and Fumarate to Resolve Pathogenicity of an SDHA Variant. | Davidoff, DF., et al. 2021. Clin Chem. 67: 696-699. PMID: 36869672
- SDHA deficient dedifferentiated gastrointestinal stromal tumour with a smooth-muscle immunophenotype. | Watts, F., et al. 2024. Pathology. 56: 127-129. PMID: 37573166
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SDHA Antibody (C-8) | sc-377302 | 200 µg/ml | $322.00 | |||
SDHA Antibody (C-8): m-IgGκ BP-HRP Bundle | sc-535557 | 200 µg Ab; 40 µg BP | $361.00 | |||
SDHA (C-8) Neutralizing Peptide | sc-377302 P | 100 µg/0.5 ml | $69.00 |