Scrib Antibody (D-2): sc-374139
- Scrib Antibody (D-2) is a mouse monoclonal IgG2a κ, cited in 6 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1489-1525 near the C-terminus of Scrib of human origin
- Anti-Scrib Antibody (D-2) is recommended for detection of Scrib of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Scrib Antibody (D-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Scrib Antibody (D-2) for WB applications. These reagents are now offered in bundles with Scrib Antibody (D-2) (see ordering information below).
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Scrib Antibody (D-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects Scrib in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Scrib (D-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Scrib plays a crucial role in maintaining epithelial integrity and regulating cell polarity, which is essential for proper tissue architecture and function. Scrib is primarily localized at tight junctions in epithelial cells, where Scrib interacts with other proteins to ensure correct assembly and maintenance of these structures. This localization is vital because tight junctions serve as barriers that control substance passage between cells, thereby influencing processes such as nutrient absorption and pathogen defense. Scrib′s PDZ domains bind to specific sequences at the C-terminus of target proteins, facilitating localization of various epithelial determinants and contributing to overall cell organization. Mutations in Scrib can lead to significant developmental defects and contribute to tumorigenesis, highlighting Scrib′s importance in both normal physiology and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Scrib Antibody (D-2) | sc-374139 | 200 µg/ml | $322.00 | |||
Scrib Antibody (D-2): m-IgG Fc BP-HRP Bundle | sc-525938 | 200 µg Ab; 10 µg BP | $361.00 | |||
Scrib Antibody (D-2): m-IgG2a BP-HRP Bundle | sc-546465 | 200 µg Ab; 10 µg BP | $361.00 | |||
Scrib Antibody (D-2) AC | sc-374139 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Scrib Antibody (D-2) HRP | sc-374139 HRP | 200 µg/ml | $322.00 | |||
Scrib Antibody (D-2) FITC | sc-374139 FITC | 200 µg/ml | $336.00 | |||
Scrib Antibody (D-2) PE | sc-374139 PE | 200 µg/ml | $349.00 | |||
Scrib Antibody (D-2) Alexa Fluor® 488 | sc-374139 AF488 | 200 µg/ml | $364.00 | |||
Scrib Antibody (D-2) Alexa Fluor® 546 | sc-374139 AF546 | 200 µg/ml | $364.00 | |||
Scrib Antibody (D-2) Alexa Fluor® 594 | sc-374139 AF594 | 200 µg/ml | $364.00 | |||
Scrib Antibody (D-2) Alexa Fluor® 647 | sc-374139 AF647 | 200 µg/ml | $364.00 | |||
Scrib Antibody (D-2) Alexa Fluor® 680 | sc-374139 AF680 | 200 µg/ml | $364.00 | |||
Scrib Antibody (D-2) Alexa Fluor® 790 | sc-374139 AF790 | 200 µg/ml | $364.00 | |||
Scrib (D-2) Neutralizing Peptide | sc-374139 P | 100 µg/0.5 ml | $69.00 |