SCCA2 Antibody (39): sc-130343

SCCA2 Antibody (39) is a mouse monoclonal IgG1 antibody that detects SCCA2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). SCCA2, a member of the serpin family, plays a crucial role in regulating serine proteases, which are enzymes that can influence various physiological processes, including inflammation and tissue remodeling. Anti-SCCA2 antibody (39) helps researchers study SCCA2′s ability to inhibit neutrophil elastase, a serine protease that, when unregulated, can contribute to tissue damage and inflammatory diseases. Aberrant expression of SCCA2 has been associated with several pathological conditions, including cancer, where SCCA2 serves as a potential biomarker for tumor progression. The SCCA2 gene is located on human chromosome 18q21.3, in close proximity to other serpin family members, and is primarily expressed in tissues affected by malignancies. Understanding SCCA2′s function and interactions with other proteins can provide insights into its role in cancer biology and therapeutic targeting. SCCA2 (39) monoclonal antibody is an essential tool for researchers investigating the mechanisms of metastasis and the role of serine protease inhibitors in disease progression.

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SCCA2 Antibody (39) References:

1. Effect of SCCA1 and SCCA2 on the suppression of TNF-alpha-induced cell death by impeding the release of mitochondrial cytochrome c in an oral squamous cell carcinoma cell line.  |  Hashimoto, K., et al. 2005. Tumour Biol. 26: 165-72. PMID: 16006770
2. Transcriptional targeting of adenovirus vectors with the squamous cell carcinoma-specific antigen-2 promoter for selective apoptosis induction in lung cancer.  |  Oshikiri, T., et al. 2006. Cancer Gene Ther. 13: 856-63. PMID: 16710347
3. Suppression of SCC antigen promotes cancer cell invasion and migration through the decrease in E-cadherin expression.  |  Murakami, A., et al. 2006. Int J Oncol. 29: 1231-5. PMID: 17016656
4. Increased expression level of squamous cell carcinoma antigen 2 and 1 ratio is associated with poor prognosis in early-stage uterine cervical cancer.  |  Hsu, KF., et al. 2007. Int J Gynecol Cancer. 17: 174-81. PMID: 17291250
5. An expression of squamous cell carcinoma antigen 2 in peripheral blood within the different stages of esophageal carcinogenesis.  |  Yang, YF., et al. 2008. Dis Esophagus. 21: 395-401. PMID: 19125792
6. The clinical value of serum squamous cell carcinoma antigens 1 and 2 in head and neck squamous cell carcinoma.  |  Yasumatsu, R., et al. 2019. Auris Nasus Larynx. 46: 135-140. PMID: 30078551
7. Measurement of squamous cell carcinoma antigen 2 in lichen planus patients.  |  Khattab, FM. and Samir, MA. 2020. J Cosmet Dermatol. 19: 1780-1784. PMID: 31815365
8. Differences in Thymus and Activation-Regulated Chemokine and Squamous Cell Carcinoma Antigen 2 Levels in Food Protein-Induced Enterocolitis Syndrome and Atopic Dermatitis.  |  Makita, E., et al. 2022. Int Arch Allergy Immunol. 183: 967-974. PMID: 35537383
9. Squamous cell carcinoma antigen 2 is a novel serpin that inhibits the chymotrypsin-like proteinases cathepsin G and mast cell chymase.  |  Schick, C., et al. 1997. J Biol Chem. 272: 1849-55. PMID: 8999871
10. An 18q- syndrome breakpoint resides between the duplicated serpins SCCA1 and SCCA2 and arises via a cryptic rearrangement with satellite III DNA.  |  Katz, SG., et al. 1999. Hum Mol Genet. 8: 87-92. PMID: 9887335

The preferred SCCA2 antibody is SCCA2 Antibody (10C12): sc-21793.