SC Antibody (SC-05): sc-51694

SC Antibody (SC-05) is a mouse monoclonal IgG1 antibody that detects secretory component (SC) in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-SC antibody (SC-05) plays a vital role in understanding mucosal immunity, as SC is essential for the stability and transport of polymeric immunoglobulins, particularly dimeric IgA and pentameric IgM, across epithelial barriers. SC is primarily located in the lamina propria beneath the mucosal lining of polarized epithelial cells, where SC interacts with polymeric immunoglobulin receptors (pIgRs) to facilitate the transcytosis of immunoglobulins. This location is significant for SC′s function as a protective mechanism, allowing secretory immunoglobulins to resist enzymatic degradation during transport, thereby maintaining their integrity and functionality in body fluids. The human SC gene, located on chromosome 1q31-q41, encodes a 764 amino acid protein that features five immunoglobulin-like domains and a transmembrane region, which are crucial for SC′s interaction with pIgRs and role in immune defense. SC monoclonal antibody (SC-05) enables researchers to gain insights into the mechanisms of mucosal immunity and the dynamics of immunoglobulin transport, contributing to a deeper understanding of immune responses in health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

SC Antibody (SC-05) References:

1. Secretory component: a potential regulator of endometrial-decidual prostaglandin production in early human pregnancy.  |  Norwitz, ER. and Wilson, T. 2000. Am J Obstet Gynecol. 183: 108-17. PMID: 10920317
2. Epithelial expression of HLA, secretory component (poly-Ig receptor), and adhesion molecules in the human alimentary tract.  |  Brandtzaeg, P., et al. 1992. Ann N Y Acad Sci. 664: 157-79. PMID: 1456647
3. Role of secretory immunoglobulin A and secretory component in the protection of mucosal surfaces.  |  Corthésy, B. 2010. Future Microbiol. 5: 817-29. PMID: 20441552
4. The structure and dynamics of secretory component and its interactions with polymeric immunoglobulins.  |  Stadtmueller, BM., et al. 2016. Elife. 5: PMID: 26943617
5. Pediatric immunoglobulin A complex secretory component deficiency.  |  Narazaki, H., et al. 2018. Pediatr Int. 60: 662-663. PMID: 30648350
6. Structural and Biochemical Requirements for Secretory Component Interactions with Dimeric IgA.  |  Kumar Bharathkar, S. and Stadtmueller, BM. 2024. J Immunol. 213: 226-234. PMID: 38809110
7. Secretory component in human ocular tissues.  |  Allansmith, MR. and Gillette, TE. 1980. Am J Ophthalmol. 89: 353-61. PMID: 6989250
8. Serum secretory IgA and secretory component in patients with non-cirrhotic alcoholic liver diseases.  |  Seillès, E., et al. 1995. J Hepatol. 22: 278-85. PMID: 7608478
9. Serum secretory IgA and IgM and free secretory component in IgA nephropathy.  |  Mole, CM., et al. 1995. Nephron. 71: 75-8. PMID: 8538852
10. Secretory component production by polarized epithelial cells from the human female reproductive tract.  |  Fahey, JV., et al. 1998. Immunol Invest. 27: 167-80. PMID: 9653665

The preferred SC antibody is SC Antibody (C-2): sc-374343.