SC Antibody (0.N.556): sc-59360
- SC Antibody (0.N.556) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against SC purified from human colostrum
- recommended for detection of both free and polymeric Ig-bound SC of mouse, rat and human origin by IF and IHC(P)
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for SC Antibody (0.N.556) for IHC(P) applications. These reagents are now offered in bundles with SC Antibody (0.N.556) (see ordering information below).
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SC Antibody (0.N.556) is a mouse monoclonal IgG1 antibody that detects secretory component (SC) in mouse, rat, and human samples through immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-SC antibody (0.N.556) is essential for understanding mucosal immunity, as SC plays a critical role in the transcellular transport of polymeric immunoglobulins, specifically dimeric IgA and IgM, across epithelial barriers. SC protects these immunoglobulins from enzymatic degradation during their journey through epithelial cells. SC is generated when polymeric immunoglobulin receptors undergo proteolytic cleavage, and associates with immunoglobulin polymers to form a stable complex that effectively traverses the mucosal lining. The human SC gene is located on chromosome 1q31-q41 and encodes a 764 amino acid protein featuring five units homologous to the variable regions of immunoglobulins, along with a transmembrane region sharing similarities with certain immunoglobulin variable regions. SC monoclonal antibody (0.N.556) helps researchers gain insights into mucosal immunity mechanisms and SC′s role in protecting against pathogens, making this antibody valuable for studies in immunology and related fields.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SC Antibody (0.N.556) References:
- Role of secretory IgA, secretory component, and eosinophils in mucosal inflammation. | Motegi, Y., et al. 2000. Int Arch Allergy Immunol. 122 Suppl 1: 25-7. PMID: 10867503
- Circulating secretory component in relation to early diagnosis and treatment of liver metastasis from colorectal carcinomas. | Kvale, D., et al. 1992. J Clin Pathol. 45: 568-71. PMID: 1517455
- The presence and measurement of secretory component in human bile and blood. | Perez, JH., et al. 1991. Clin Chim Acta. 197: 171-87. PMID: 1710954
- A comparison of the binding of secretory component to immunoglobulin A (IgA) in human colostral S-IgA1 and S-IgA2. | Almogren, A., et al. 2007. Immunology. 120: 273-80. PMID: 17156102
- Synthesis of secretory component by colonic neoplasms. | Poger, ME., et al. 1976. Am J Pathol. 82: 327-38. PMID: 175662
- Elevated free secretory component in early rheumatoid arthritis and prior to arthritis development in patients at increased risk. | Martinsson, K., et al. 2020. Rheumatology (Oxford). 59: 979-987. PMID: 31504979
- Circulating anti-citrullinated protein antibodies containing secretory component are prognostic for arthritis onset in at-risk patients. | Roos Ljungberg, K., et al. 2021. Clin Exp Immunol. 204: 344-351. PMID: 33675063
- Secretory component of epithelial cells is a surface receptor for polymeric immunoglobulins. | Crago, SS., et al. 1978. J Exp Med. 147: 1832-7. PMID: 681880
- The covalent linkage of secretory component to IgA. Structure of sIgA. | Fallgreen-Gebauer, E., et al. 1993. Biol Chem Hoppe Seyler. 374: 1023-8. PMID: 8292260
- Secretory component production by human bronchial epithelial cells is upregulated by interferon gamma. | Godding, V., et al. 1998. Eur Respir J. 11: 1043-52. PMID: 9648953
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SC Antibody (0.N.556) | sc-59360 | 200 µg/ml | $316.00 | |||
SC Antibody (0.N.556): m-IgG Fc BP-HRP Bundle | sc-539131 | 200 µg Ab; 10 µg BP | $354.00 | |||
SC Antibody (0.N.556): m-IgG1 BP-HRP Bundle | sc-541282 | 200 µg Ab; 20 µg BP | $354.00 |