SBNO2 Antibody (A-3): sc-515634
- SBNO2 Antibody (A-3) is a mouse monoclonal IgG2b κ SBNO2 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1091-1113 within an internal region of SBNO2 of human origin
- SBNO2 Antibody (A-3) is recommended for detection of SBNO2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-SBNO2 Antibody (A-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-515634 X, 200 µg/0.1 ml)
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SBNO2 Antibody (A-3) for WB applications. These reagents are now offered in bundles with SBNO2 Antibody (A-3) (see ordering information below).
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SBNO2 Antibody (A-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects SBNO2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SBNO2 Antibody (A-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SBNO2, also known as strawberry notch homolog 2, is a 1,366 amino acid protein that plays a crucial role in transcriptional repression, particularly in macrophages, where SBNO2 contributes to the anti-inflammatory effects of interleukin-10 (IL-10). IL-10 regulates SBNO2 expression in a Stat3-dependent manner, highlighting SBNO2′s importance in immune response modulation. SBNO2 exists in two alternatively spliced isoforms and is conserved across various species, including chimpanzees, dogs, cows, mice, rats, chickens, zebrafish, and Caenorhabditis elegans, mapping to human chromosome 19p13.3. SBNO2 is located near key genes such as GPx-4 and LKB1, which are also implicated in various biological processes. Chromosome 19, which houses SBNO2, contains approximately 63 million bases and is associated with several genetic conditions, including Peutz-Jeghers syndrome and spinocerebellar ataxia type 6, underscoring SBNO2′s relevance in both health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SBNO2 Antibody (A-3) References:
- Analysis of candidate genes on chromosome 19 in coeliac disease: an association study of the KIR and LILR gene clusters. | Moodie, SJ., et al. 2002. Eur J Immunogenet. 29: 287-91. PMID: 12121272
- The DNA sequence and biology of human chromosome 19. | Grimwood, J., et al. 2004. Nature. 428: 529-35. PMID: 15057824
- A novel CADASIL-causing mutation in a stroke patient. | Vikelis, M., et al. 2007. Swiss Med Wkly. 137: 323-5. PMID: 17629811
- Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway. | El Kasmi, KC., et al. 2007. J Immunol. 179: 7215-9. PMID: 18025162
- Homozygous deletion of the STK11/LKB1 locus and the generation of novel fusion transcripts in cervical cancer cells. | McCabe, MT., et al. 2010. Cancer Genet Cytogenet. 197: 130-41. PMID: 20193846
- High prevalence of germline STK11 mutations in Hungarian Peutz-Jeghers Syndrome patients. | Papp, J., et al. 2010. BMC Med Genet. 11: 169. PMID: 21118512
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SBNO2 Antibody (A-3) | sc-515634 | 200 µg/ml | $322.00 | |||
SBNO2 Antibody (A-3): m-IgGκ BP-HRP Bundle | sc-525141 | 200 µg Ab, 40 µg BP | $361.00 | |||
SBNO2 Antibody (A-3): m-IgG2b BP-HRP Bundle | sc-549215 | 200 µg Ab; 10 µg BP | $361.00 | |||
SBNO2 Antibody (A-3) X | sc-515634 X | 200 µg/0.1 ml | $322.00 | |||
SBNO2 Antibody (A-3) AC | sc-515634 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SBNO2 Antibody (A-3) HRP | sc-515634 HRP | 200 µg/ml | $322.00 | |||
SBNO2 Antibody (A-3) FITC | sc-515634 FITC | 200 µg/ml | $336.00 | |||
SBNO2 Antibody (A-3) PE | sc-515634 PE | 200 µg/ml | $349.00 | |||
SBNO2 Antibody (A-3) Alexa Fluor® 488 | sc-515634 AF488 | 200 µg/ml | $364.00 | |||
SBNO2 Antibody (A-3) Alexa Fluor® 546 | sc-515634 AF546 | 200 µg/ml | $364.00 | |||
SBNO2 Antibody (A-3) Alexa Fluor® 594 | sc-515634 AF594 | 200 µg/ml | $364.00 | |||
SBNO2 Antibody (A-3) Alexa Fluor® 647 | sc-515634 AF647 | 200 µg/ml | $364.00 | |||
SBNO2 Antibody (A-3) Alexa Fluor® 680 | sc-515634 AF680 | 200 µg/ml | $364.00 | |||
SBNO2 Antibody (A-3) Alexa Fluor® 790 | sc-515634 AF790 | 200 µg/ml | $364.00 | |||
SBNO2 (A-3) Neutralizing Peptide | sc-515634 P | 100 µg/0.5 ml | $69.00 |