SAV1 Antibody (JJ-6): sc-101205
- SAV1 Antibody (JJ-6) is a mouse monoclonal IgG2a κ, cited in 4 publications, provided at 100 µg/ml
- raised against recombinant SAV1 of human origin
- recommended for detection of SAV1 of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SAV1 Antibody (JJ-6). This work is in progress.
QUICK LINKS
SAV1 Antibody (JJ-6) is a mouse monoclonal IgG2a antibody that detects SAV1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SAV1, also known as Salvador homolog 1, WW45, or WWP4, is a crucial protein involved in the regulation of the Hippo signaling pathway, which plays a significant role in controlling cell growth and apoptosis. SAV1 features one SARAH domain and two WW domains, with the SARAH domain facilitating protein-protein interactions essential for cell cycle regulation. Notably, SAV1 can form homodimers and acts as a scaffold protein, enabling the binding of Krs-2, a key regulator that restricts cell proliferation and promotes apoptosis. This interaction is vital for the nuclear translocation and activation of Krs-2, which subsequently leads to the phosphorylation of major tumor suppressors LATS1 and kpm. Proper functioning of SAV1 is critical, as defects in the Hippo pathway have been linked to tumorigenesis, indicating that dysfunctional SAV1 may contribute to the development of various cancers. With an ability to provide insights into the mechanisms of cell cycle regulation and apoptosis, anti-SAV1 antibody (JJ-6) is an invaluable tool for researchers studying cancer biology and related fields.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SAV1 Antibody (JJ-6) References:
- SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK. | Bae, SJ., et al. 2017. Elife. 6: PMID: 29063833
- SAV1, regulated by microRNA-21, suppresses tumor growth in colorectal cancer. | Jiang, J., et al. 2019. Biochem Cell Biol. 97: 91-99. PMID: 30681889
- STK25 suppresses Hippo signaling by regulating SAV1-STRIPAK antagonism. | Bae, SJ., et al. 2020. Elife. 9: PMID: 32292165
- A WW Tandem-Mediated Dimerization Mode of SAV1 Essential for Hippo Signaling. | Lin, Z., et al. 2020. Cell Rep. 32: 108118. PMID: 32905778
- SAV1, regulated by HERC4, inhibits the proliferation, migration, and invasion of hepatocellular carcinoma. | Huang, F., et al. 2021. Transl Cancer Res. 10: 349-360. PMID: 35116265
- Novel KDM2B/SAV1 Signaling Pathway Promotes the Progression of Gastric Cancer. | Li, N., et al. 2023. Genet Res (Camb). 2023: 1230182. PMID: 37033161
- Enhanced SLC35B2/SAV1 sulfation axis promotes tumor growth by inhibiting Hippo signaling in HCC. | He, B., et al. 2025. Hepatology. 81: 436-452. PMID: 38377452
- GRK2 mediated degradation of SAV1 initiates hyperplasia of fibroblast-like synoviocytes in rheumatoid arthritis. | Guo, P., et al. 2024. Acta Pharm Sin B. 14: 1222-1240. PMID: 38486990
- Loss of SAV1 in Kidney Proximal Tubule Induces Maladaptive Repair after Ischemia and Reperfusion Injury. | Moon, D., et al. 2024. Int J Mol Sci. 25: PMID: 38731829
- Whole-exome sequencing reveals genomic landscape of intrahepatic cholangiocarcinoma and identifies SAV1 as a potential driver. | Zhou, ZJ., et al. 2024. Nat Commun. 15: 9960. PMID: 39551842
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SAV1 Antibody (JJ-6) | sc-101205 | 100 µg/ml | $339.00 |