saposin C Antibody (B-10): sc-374119
- saposin C Antibody (B-10) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 311-391 mapping within an internal region of saposin C of human origin
- recommended for detection of prosaposin and mature saposin C of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for saposin C Antibody (B-10) for WB and IHC(P) applications. These reagents are now offered in bundles with saposin C Antibody (B-10) (see ordering information below).
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Saposin C Antibody (B-10) is a mouse monoclonal IgG2a antibody that detects saposin C in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Saposin C plays a crucial role in lysosomal degradation of glycosphingolipids, acting as an essential cofactor for specific hydrolase enzymes. By modifying the lipid environment, saposin C enhances the accessibility of these enzymes to their substrates, thereby facilitating the breakdown of complex lipids. This function is particularly important in cellular metabolism and lipid homeostasis, as defects in saposin C have been linked to Gaucher′s disease, a genetic disorder characterized by glucocerebroside accumulation due to insufficient enzyme activity. Saposin C′s interaction with glucosylceramidase underscores saposin C′s significance in lysosomal function and highlights the potential consequences of dysfunction, making anti-saposin C antibody (B-10) a valuable tool for researchers studying lipid metabolism and related pathologies.
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saposin C Antibody (B-10) References:
- Associations of saposin C, Src, and androgen receptor upregulate the expression and function of androgen receptor in human prostate cancer cells. | Ding, Y., et al. 2011. J Cell Biochem. 112: 818-28. PMID: 21328455
- Saposin C protects glucocerebrosidase against α-synuclein inhibition. | Yap, TL., et al. 2013. Biochemistry. 52: 7161-3. PMID: 24070323
- The effects of chemically synthesized saposin C on glucosylceramide-β-glucosidase. | Yoneshige, A., et al. 2015. Clin Biochem. 48: 1177-80. PMID: 26068040
- Sequencing of the GBA coactivator, Saposin C, in Parkinson disease. | Ouled Amar Bencheikh, B., et al. 2018. Neurobiol Aging. 72: 187.e1-187.e3. PMID: 30037697
- Saposin C is a frequent target of paraproteins in Gaucher disease-associated MGUS/multiple myeloma. | Preuss, KD., et al. 2019. Br J Haematol. 184: 384-391. PMID: 30450574
- Glucosylsphingosine but not Saposin C, is the target antigen in Gaucher disease-associated gammopathy. | Nair, S., et al. 2020. Mol Genet Metab. 129: 286-291. PMID: 32044242
- Engineering of Saposin C Protein Chimeras for Enhanced Cytotoxicity and Optimized Liposome Binding Capability. | Sandin, SI., et al. 2021. Pharmaceutics. 13: PMID: 33921905
- Targeting of elevated cell surface phosphatidylserine with saposin C-dioleoylphosphatidylserine nanodrug as individual or combination therapy for pancreatic cancer. | Davis, HW., et al. 2021. World J Gastrointest Oncol. 13: 550-559. PMID: 34163572
- Prosaposin Reduces α-Synuclein in Cells and Saposin C Dislodges it from Glucosylceramide-enriched Lipid Membranes. | Kojima, R., et al. 2022. J Mol Neurosci. 72: 2313-2325. PMID: 36152140
- Functional organization of saposin C. Definition of the neurotrophic and acid beta-glucosidase activation regions. | Qi, X., et al. 1996. J Biol Chem. 271: 6874-80. PMID: 8636113
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
saposin C Antibody (B-10) | sc-374119 | 200 µg/ml | $322.00 | |||
saposin C Antibody (B-10): m-IgGκ BP-HRP Bundle | sc-535389 | 200 µg Ab; 40 µg BP | $361.00 | |||
saposin C Antibody (B-10): m-IgG2a BP-HRP Bundle | sc-546226 | 200 µg Ab; 10 µg BP | $361.00 |