SAPK4 Antibody (D-2): sc-376437

SAPK4 Antibody (D-2) is a mouse monoclonal IgG1 antibody that detects SAPK4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SAPK4, also known as p38d, is a member of the mitogen-activated protein kinase (MAPK) family, which plays a crucial role in cellular responses to stress and inflammation. SAPK4 is primarily located in the cytoplasm and is activated in response to various stimuli, including cytokines and environmental stressors, highlighting its importance in regulating cellular signaling pathways that govern cell survival, differentiation, and apoptosis. The unique TGY phosphorylation motif of SAPK4 distinguishes it from other MAPK family members, allowing SAPK4 to interact with specific substrates and modulate distinct signaling cascades. Notably, SAPK4 is phosphorylated by MKK6, which underscores its role in mediating cellular responses to stress. Anti-SAPK4 antibody (D-2) is an essential tool for researchers investigating the intricate mechanisms of stress signaling and the functional implications of SAPK4 in various biological processes.

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SAPK4 Antibody (D-2) References:

1. Constitutive activity and differential localization of p38alpha and p38beta MAPKs in adult mouse brain.  |  Lee, SH., et al. 2000. J Neurosci Res. 60: 623-31. PMID: 10820433
2. p38alpha, but not p38beta, inhibits the phosphorylation and presence of c-FLIPS in DISC to potentiate Fas-mediated caspase-8 activation and type I apoptotic signaling.  |  Tourian, L., et al. 2004. J Cell Sci. 117: 6459-71. PMID: 15572410
3. Sequential phosphorylation of tau protein by cAMP-dependent protein kinase and SAPK4/p38delta or JNK2 in the presence of heparin generates the AT100 epitope.  |  Yoshida, H. and Goedert, M. 2006. J Neurochem. 99: 154-64. PMID: 16987243
4. Efficient adult skeletal muscle regeneration in mice deficient in p38beta, p38gamma and p38delta MAP kinases.  |  Ruiz-Bonilla, V., et al. 2008. Cell Cycle. 7: 2208-14. PMID: 18641461
5. p38β MAP kinase as a therapeutic target for pancreatic cancer.  |  Singh, AK., et al. 2012. Chem Biol Drug Des. 80: 266-73. PMID: 22515544
6. Coronin 1A depletion protects endothelial cells from TNFα-induced apoptosis by modulating p38β expression and activation.  |  Kim, GY., et al. 2015. Cell Signal. 27: 1688-93. PMID: 25936522
7. Clinicopathological significance of p38β, p38γ, and p38δ and its biological roles in esophageal squamous cell carcinoma.  |  Zheng, S., et al. 2016. Tumour Biol. 37: 7255-66. PMID: 26666822
8. Estrogen Protects the Female Heart from Ischemia/Reperfusion Injury through Manganese Superoxide Dismutase Phosphorylation by Mitochondrial p38β at Threonine 79 and Serine 106.  |  Luo, T., et al. 2016. PLoS One. 11: e0167761. PMID: 27930699
9. p38β Mitogen-Activated Protein Kinase Signaling Mediates Exenatide-Stimulated Microglial β-Endorphin Expression.  |  Wu, HY., et al. 2017. Mol Pharmacol. 91: 451-463. PMID: 28202578
10. Intrathecal administration of antisense oligonucleotide against p38α but not p38β MAP kinase isoform reduces neuropathic and postoperative pain and TLR4-induced pain in male mice.  |  Luo, X., et al. 2018. Brain Behav Immun. 72: 34-44. PMID: 29128611

The preferred SAPK4 antibody is SAPK4 Antibody (E-7): sc-46678.