SAPK4 Antibody (20): sc-136063
- SAPK4 Antibody (20) is a mouse monoclonal IgG1, cited in 1 publications, provided at 50 µg/0.5 ml
- raised against amino acids 224-345 of SAPK4 of human origin
- recommended for detection of SAPK4 of mouse, rat and human origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SAPK4 Antibody (20). This work is in progress.
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SAPK4 Antibody (20) is a mouse monoclonal IgG1 antibody that detects SAPK4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). SAPK4, also known as p38δ, is a member of the mitogen-activated protein kinase (MAPK) family and plays a crucial role in cellular responses to stress and cytokines. SAPK4 is primarily located in the cytoplasm, where activation occurs in response to various stress signals, including inflammatory cytokines and environmental stressors. SAPK4′s localization enables rapid signaling cascades that can lead to important cellular outcomes, such as apoptosis, differentiation, and inflammation. SAPK4 interacts with several key proteins, including MKK6, which phosphorylates and activates SAPK4, allowing regulation of downstream targets involved in stress responses. The unique phosphorylation sequence of SAPK4, which includes a TGY motif, distinguishes SAPK4 from other MAPK family members and highlights a specialized role in cellular signaling pathways. Anti-SAPK4 antibody (20) is an essential tool for researchers studying the intricate mechanisms of stress signaling and the functional implications of SAPK4 in various biological contexts.
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SAPK4 Antibody (20) References:
- Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression. | Mahlknecht, U., et al. 2004. J Immunol. 173: 3979-90. PMID: 15356147
- Spinal p38beta isoform mediates tissue injury-induced hyperalgesia and spinal sensitization. | Svensson, CI., et al. 2005. J Neurochem. 92: 1508-20. PMID: 15748168
- Chemical genetics define the roles of p38alpha and p38beta in acute and chronic inflammation. | O'Keefe, SJ., et al. 2007. J Biol Chem. 282: 34663-71. PMID: 17855341
- COX-2 promoter activation by AT1R-Gq-PAK-p38beta signaling in intestinal epithelial cells. | Pham, H., et al. 2008. Biochim Biophys Acta. 1779: 408-13. PMID: 18515110
- Inhibition of neuronal p38α, but not p38β MAPK, provides neuroprotection against three different neurotoxic insults. | Xing, B., et al. 2015. J Mol Neurosci. 55: 509-18. PMID: 25012593
- Activin A induces tumorigenesis of leiomyoma via regulation of p38β MAPK-mediated signal cascade. | Bao, H., et al. 2020. Biochem Biophys Res Commun. 529: 379-385. PMID: 32703439
- Weight Loss in Cancer Patients Correlates With p38β MAPK Activation in Skeletal Muscle. | Zhang, G., et al. 2021. Front Cell Dev Biol. 9: 784424. PMID: 34950660
- Microarray meta-analysis reveals IL6 and p38β/MAPK11 as potential targets of hsa-miR-124 in endothelial progenitor cells: Implications for stent re-endothelization in diabetic patients. | Arencibia, A. and Salazar, LA. 2022. Front Cardiovasc Med. 9: 964721. PMID: 36176980
- Tracheal agenesis versus tracheal atresia: anatomical conditions, pathomechanisms and causes with a possible link to a novel MAPK11 variant in one case. | Pfeifer, M., et al. 2024. Orphanet J Rare Dis. 19: 114. PMID: 38475835
- Activation of the novel MAP kinase homologue SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6). | Cuenda, A., et al. 1997. Biochem Soc Trans. 25: S569. PMID: 9449997
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SAPK4 Antibody (20) | sc-136063 | 50 µg/0.5 ml | $316.00 |