SAMD12 Antibody (A-6): sc-377123
- SAMD12 Antibody (A-6) is a mouse monoclonal IgG1 κ SAMD12 antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 3-29 near the N-terminus of SAMD12 of human origin
- SAMD12 Antibody (A-6) is recommended for detection of SAMD12 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including bovine
- Anti-SAMD12 Antibody (A-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SAMD12 Antibody (A-6) for WB applications. These reagents are now offered in bundles with SAMD12 Antibody (A-6) (see ordering information below).
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SAMD12 Antibody (A-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects SAMD12 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SAMD12 (A-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SAMD12 protein, also known as Sterile alpha motif domain-containing protein 12, plays a crucial role in cellular processes due to involvement in RNA binding, which is essential for regulating gene expression and maintaining cellular homeostasis. SAMD12 consists of 201 amino acids and is encoded by the SAMD12 gene located on human chromosome 8, a chromosome that harbors over 800 genes and is linked to several diseases, including schizophrenia and various malignancies. The presence of the sterile alpha motif (SAM) domain, a 70-residue structure characterized by a five-helix bundle, allows SAMD12 to interact with other proteins and RNA, thereby influencing critical biological pathways. Understanding SAMD12 function and interactions is vital for elucidating its role in health and disease, making anti-SAMD12 antibody (A-6) an invaluable tool for researchers studying these mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SAMD12 Antibody (A-6) References:
- Chromosomes 8 and 10 workshop. | Wildenauer, DB. and Schwab, SG. 1999. Am J Med Genet. 88: 239-43. PMID: 10374738
- Solution structure of the receptor tyrosine kinase EphB2 SAM domain and identification of two distinct homotypic interaction sites. | Smalla, M., et al. 1999. Protein Sci. 8: 1954-61. PMID: 10548040
- SAM domains: uniform structure, diversity of function. | Kim, CA. and Bowie, JU. 2003. Trends Biochem Sci. 28: 625-8. PMID: 14659692
- RNA-Seq detects a SAMD12-EXT1 fusion transcript and leads to the discovery of an EXT1 deletion in a child with multiple osteochondromas. | Oliver, GR., et al. 2019. Mol Genet Genomic Med. 7: e00560. PMID: 30632316
- Intronic (TTTGA)n insertion in SAMD12 also causes familial cortical myoclonic tremor with epilepsy. | Cen, Z., et al. 2019. Mov Disord. 34: 1571-1576. PMID: 31483537
- TTTCA Repeat Expansion of SAMD12 in a New Benign Adult Familial Myoclonic Epilepsy Pedigree. | Liu, C., et al. 2020. Front Neurol. 11: 68. PMID: 32174879
- Liver fibrosis-derived exosomal miR-106a-5p facilitates the malignancy by targeting SAMD12 and CADM2 in hepatocellular carcinoma. | Hu, J., et al. 2023. PLoS One. 18: e0286017. PMID: 37228062
- Generation of an induced pluripotent stem cell line (ZJUi013-A) from a Familial cortical myoclonic tremor with epilepsy type 1 patient carrying (TTTCA)n insertion in the SAMD12 gene. | Zhang, F., et al. 2023. Stem Cell Res. 73: 103236. PMID: 37890330
- SAM as a protein interaction domain involved in developmental regulation. | Schultz, J., et al. 1997. Protein Sci. 6: 249-53. PMID: 9007998
- The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization. | Stapleton, D., et al. 1999. Nat Struct Biol. 6: 44-9. PMID: 9886291
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SAMD12 Antibody (A-6) | sc-377123 | 200 µg/ml | $322.00 | |||
SAMD12 Antibody (A-6): m-IgG Fc BP-HRP Bundle | sc-529981 | 200 µg Ab; 10 µg BP | $361.00 | |||
SAMD12 Antibody (A-6): m-IgGκ BP-HRP Bundle | sc-523200 | 200 µg Ab, 40 µg BP | $361.00 | |||
SAMD12 Antibody (A-6): m-IgG1 BP-HRP Bundle | sc-543800 | 200 µg Ab; 20 µg BP | $361.00 | |||
SAMD12 Antibody (A-6) AC | sc-377123 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SAMD12 Antibody (A-6) HRP | sc-377123 HRP | 200 µg/ml | $322.00 | |||
SAMD12 Antibody (A-6) FITC | sc-377123 FITC | 200 µg/ml | $336.00 | |||
SAMD12 Antibody (A-6) PE | sc-377123 PE | 200 µg/ml | $349.00 | |||
SAMD12 Antibody (A-6) Alexa Fluor® 488 | sc-377123 AF488 | 200 µg/ml | $364.00 | |||
SAMD12 Antibody (A-6) Alexa Fluor® 546 | sc-377123 AF546 | 200 µg/ml | $364.00 | |||
SAMD12 Antibody (A-6) Alexa Fluor® 594 | sc-377123 AF594 | 200 µg/ml | $364.00 | |||
SAMD12 Antibody (A-6) Alexa Fluor® 647 | sc-377123 AF647 | 200 µg/ml | $364.00 | |||
SAMD12 Antibody (A-6) Alexa Fluor® 680 | sc-377123 AF680 | 200 µg/ml | $364.00 | |||
SAMD12 Antibody (A-6) Alexa Fluor® 790 | sc-377123 AF790 | 200 µg/ml | $364.00 | |||
SAMD12 (A-6) Neutralizing Peptide | sc-377123 P | 100 µg/0.5 ml | $69.00 |