Sam 68 Antibody (15): sc-136062
- Sam 68 Antibody (15) is a mouse monoclonal IgG1, cited in 1 publications, provided at 50 µg/0.5 ml
- raised against amino acids 91-272 of Sam 68 of human origin
- recommended for detection of Sam 68 of mouse, rat, human, bovine and canine origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Sam 68 Antibody (15). This work is in progress.
QUICK LINKS
SEE ALSO...
Sam 68 Antibody (15) is a mouse monoclonal IgG1 antibody that detects Sam 68 in mouse, rat, human, bovine, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Sam 68 is a multifunctional protein that plays a crucial role in cellular signaling and RNA metabolism, primarily functioning as an adapter protein that interacts with various signaling molecules, including GRB2 and PLC γ1. Sam 68 (15) antibody recognizes a protein whose tyrosine phosphorylation regulates interactions and functions during mitosis, thereby influencing cell proliferation and differentiation. Sam 68 phosphorylation modulates the activity of Src family tyrosine kinases, which are vital for transmitting signals from growth factor receptors to downstream effectors. Sam 68′s presence in the cytoplasm and nucleus highlights involvement in both cytoplasmic signaling pathways and nuclear processes, such as RNA splicing and transport. Sam 68′s versatility in mediating these critical cellular functions underscores significance in various physiological and pathological contexts, making anti-Sam 68 antibody (15) an essential tool for researchers studying cell signaling and gene expression regulation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Sam 68 Antibody (15) References:
- The RNA-binding protein Sam68 is a multifunctional player in human cancer. | Bielli, P., et al. 2011. Endocr Relat Cancer. 18: R91-R102. PMID: 21565971
- SAM68: Signal Transduction and RNA Metabolism in Human Cancer. | Frisone, P., et al. 2015. Biomed Res Int. 2015: 528954. PMID: 26273626
- Sam68 Promotes the Progression of Human Breast Cancer through inducing Activation of EphA3. | Chen, X., et al. 2020. Curr Cancer Drug Targets. 20: 76-83. PMID: 31433759
- Leptin, Adiponectin, and Sam68 in Bone Metastasis from Breast Cancer. | Maroni, P. 2020. Int J Mol Sci. 21: PMID: 32033341
- SAM68 promotes tumorigenesis in lung adenocarcinoma by regulating metabolic conversion via PKM alternative splicing. | Zhu, S., et al. 2021. Theranostics. 11: 3359-3375. PMID: 33537092
- Ablation of Sam68 in adult mice increases thermogenesis and energy expenditure. | Qiao, A., et al. 2021. FASEB J. 35: e21772. PMID: 34252225
- Sam68 contributes to intestinal inflammation in experimental and human colitis. | Goodman, WA., et al. 2021. Cell Mol Life Sci. 78: 7635-7648. PMID: 34693458
- Role of Sam68 in Sunitinib induced renal cell carcinoma apoptosis. | Wu, Z., et al. 2022. Cancer Med. 11: 3674-3686. PMID: 35476809
- Hepatic Sam68 Regulates Systemic Glucose Homeostasis and Insulin Sensitivity. | Qiao, A., et al. 2022. Int J Mol Sci. 23: PMID: 36232770
- Sam68 promotes osteogenic differentiation of aortic valvular interstitial cells by TNF-α/STAT3/autophagy axis. | Liu, X., et al. 2023. J Cell Commun Signal. 17: 863-879. PMID: 36847917
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sam 68 Antibody (15) | sc-136062 | 50 µg/0.5 ml | $316.00 |